Study of Lung Health Among Workers Exposed to Diesel Exhaust
NCT ID: NCT01867450
Last Updated: 2020-11-13
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
109 participants
OBSERVATIONAL
2013-03-28
2020-11-12
Brief Summary
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\- Diesel fuel is the most commonly used fuel to power cars and trucks worldwide. However, diesel exhaust fumes can have harmful effects on the body. Researchers are interested in studying how diesel exhaust exposure can affect lung health. To study these effects, researchers will look at employees of a diesel truck engine testing facility in China. Some workers at this facility are exposed to high levels of diesel exhaust. This study will compare tests and monitoring information from a group of highly exposed workers and a similar group of unexposed comparable controls.
Objectives:
* To study the effects of diesel exhaust on lung health.
Eligibility:
* Participants will be drawn from a diesel truck engine testing facility and other workplaces in China.
* Individuals at least 18 years of age who work in workshops with diesel fuel.
* Individuals at least 18 years of age who work in workshops that do not use diesel fuel.
Design:
* Depending on what type of factory study subjects work in, participants will wear personal air pumps and small badges on their clothing on one or more days. This equipment will measure particles, chemicals, and other compounds in the air. This information plus other information collected in the study including workplace practices will be used to estimate exposure to diesel exhaust among study subjects.
* Participants will provide a number of study samples. These samples include blood, urine, and sputum. To collect other samples, participants will also have a mouth rinse, cheek cell scrapes, and nasal cell scrapes. They will also have a physical exam.
* Treatment will not be provided as part of this study. Participants will receive financial compensation for participation in the study.
Detailed Description
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Conditions
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Keywords
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Study Design
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OTHER
CROSS_SECTIONAL
Study Groups
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Biomarker Cross-section
Cross-sectional biomarker study in Chinese diesel workers
No interventions assigned to this group
Eligibility Criteria
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Inclusion Criteria
To be a current male worker in a selected control study factory, that does not have exposure to diesel exhaust or other types of particulates, or any known or suspected genotoxic, hematotoxic, or immunotoxic chemicals, who is comparable to workers working in the diesel engine testing facility by age and smoking status .
Exclusion Criteria
18 Years
70 Years
ALL
No
Sponsors
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Utrecht University
OTHER
Boston University
OTHER
University of Cincinnati
OTHER
University of Southern California
OTHER
Duke University
OTHER
National Cancer Institute (NCI)
NIH
Responsible Party
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Principal Investigators
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Qing Lan, M.D.
Role: PRINCIPAL_INVESTIGATOR
National Cancer Institute (NCI)
Locations
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Chinese Center for Disease Control & Prevention
Beijing, , China
Countries
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References
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Chang JT, Nevins JR. GATHER: a systems approach to interpreting genomic signatures. Bioinformatics. 2006 Dec 1;22(23):2926-33. doi: 10.1093/bioinformatics/btl483. Epub 2006 Sep 25.
Gerlofs-Nijland ME, Totlandsdal AI, Kilinc E, Boere AJ, Fokkens PH, Leseman DL, Sioutas C, Schwarze PE, Spronk HM, Hadoke PW, Miller MR, Cassee FR. Pulmonary and cardiovascular effects of traffic-related particulate matter: 4-week exposure of rats to roadside and diesel engine exhaust particles. Inhal Toxicol. 2010 Dec;22(14):1162-73. doi: 10.3109/08958378.2010.531062.
Gordon CJ, Schladweiler MC, Krantz T, King C, Kodavanti UP. Cardiovascular and thermoregulatory responses of unrestrained rats exposed to filtered or unfiltered diesel exhaust. Inhal Toxicol. 2012 Apr;24(5):296-309. doi: 10.3109/08958378.2012.670811.
Other Identifiers
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13-C-N101
Identifier Type: -
Identifier Source: secondary_id
999913101
Identifier Type: -
Identifier Source: org_study_id