Efficacy, Safety And Tolerability Study Of RN6G In Subjects With Geographic Atrophy Secondary to Age-related Macular Degeneration
NCT ID: NCT01577381
Last Updated: 2016-03-16
Study Results
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View full resultsBasic Information
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TERMINATED
PHASE2
10 participants
INTERVENTIONAL
2012-08-31
2013-10-31
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
QUADRUPLE
Study Groups
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PF-04382923
RN6G
Intravenous, 11 doses, 30 minute infusion, dose ranging from 2.5 mg/kg up to a maximum of 15 mg/kg
Placebo
Placebo
Intravenous, 11 doses, 30 minute infusion
Interventions
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RN6G
Intravenous, 11 doses, 30 minute infusion, dose ranging from 2.5 mg/kg up to a maximum of 15 mg/kg
Placebo
Intravenous, 11 doses, 30 minute infusion
Eligibility Criteria
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Inclusion Criteria
* Diagnosis of a geographic atrophy (GA) secondary to dry Age-Related Macular Degeneration.
* Best Corrected Visual Acuity (BCVA) of 20/80 or better in the study eye
Exclusion Criteria
* History or diagnosis of exudative (wet) Age-Related Macular Degeneration, with subretinal or choroidal neovascular lesions in the study eye.
* Presence of disease or condition that might compromise the cardiovascular, hematological, renal, hepatic, pulmonary, endocrine, central nervous, immune, or gastrointestinal system
60 Years
90 Years
ALL
No
Sponsors
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Pfizer
INDUSTRY
Responsible Party
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Principal Investigators
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Pfizer CT.gov Call Center
Role: STUDY_DIRECTOR
Pfizer
Locations
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Scottsdale Medical Imaging
Phoenix, Arizona, United States
Associated Retina Consultants, Ltd.
Phoenix, Arizona, United States
Premier Research Group Limited
Phoenix, Arizona, United States
Radiology Limited
Tucson, Arizona, United States
Retina Associates
Tucson, Arizona, United States
Reeds Compounding Pharmacy
Tucson, Arizona, United States
Methodist Hospital of Southern California
Arcadia, California, United States
Retina Institute of California
Arcadia, California, United States
Mink Radiologic Imaging
Beverly Hills, California, United States
Retina Vitreous Associates Medical Group
Beverly Hills, California, United States
Retina-Vitreous Associates Medical Group
Beverly Hills, California, United States
Northern California Retina Vitreous Associates
Mountain View, California, United States
Valley Radiology Medical Associates, Inc.
Mountain View, California, United States
Fairmount Pharmacy
Pasadena, California, United States
Radiological Associates of Sacramento Medical Group, Inc. (MRI Imaging Only)
Roseville, California, United States
Retinal Consultants Medical Group, Inc.
Sacramento, California, United States
Leiter's Compounding Pharmacy
San Jose, California, United States
Cardiology Specialist of Orange County (ECG Evaluation Only)
Santa Ana, California, United States
Kenneth L. Nudleman M.D. (Neurology Exam Only)
Santa Ana, California, United States
Open Advantage MRI (Brain MRI Only)
Santa Ana, California, United States
Orange County Retina Medical Group
Santa Ana, California, United States
Quest Diagnostics Patient Service Center (Blood Draw Lab only)
Santa Ana, California, United States
Florida Eye Clinic
Altamonte Springs, Florida, United States
Maitland Avenue Urgent Care (Physical and Neurologic Exams Only)
Altamonte Springs, Florida, United States
Mid Florida Imaging (MRI Only)
Altamonte Springs, Florida, United States
Center for Retina and Macular Disease
Lakeland, Florida, United States
Medeye Associates
Miami, Florida, United States
Open MRI & CT of South Miami
Miami, Florida, United States
Retina Care Specialists, LLP
Palm Beach Gardens, Florida, United States
Premiere Research Institute At Palm Beach Neurology (MRI, Physical Exam, and Neurological Exam Only)
West Palm Beach, Florida, United States
Sabates Eye Center Research Division
Leawood, Kansas, United States
O'Brien Pharmacy (Drug Shipment Only)
Mission, Kansas, United States
Diagnostic Imaging (MRI Only)
Overland Park, Kansas, United States
Apothecary By Design
Portland, Maine, United States
Charles Cathcart M.D.
Portland, Maine, United States
Maine Eye Center
Portland, Maine, United States
Intermed Diagnostic Imaging
South Portland, Maine, United States
Advanced Open MRI
Toms River, New Jersey, United States
Retina Vitreous Center
Toms River, New Jersey, United States
Shore Neurology, PA
Toms River, New Jersey, United States
King's Pharmacy
Brooklyn, New York, United States
Zwager - Pesiri Radiology Group - MRI Exam Facility Only
East Setauket, New York, United States
Advanced Neurological Care, PC - Neurology Exam Facility Only
Lynbrook, New York, United States
Ophthalmic Consultants of Long Island
Lynbrook, New York, United States
Zwager - Pesiri Radiology Group - MRI Exam Facility Only
Merrick, New York, United States
Lenox Hill Radiology/Regency Medical Imaging (MRI Only)
New York, New York, United States
Macula Care, Pllc
New York, New York, United States
Lenox Hill Radiology (MRI Only)
New York, New York, United States
Zwager - Pesiri Radiology Group - MRI Exam Facility Only
Plainview, New York, United States
Cardiology Consultants of Long Island, PC- Physical Exam Facility Only
Rockville Centre, New York, United States
Advanced Neurological Care, PC - Neurology Exam Facility Only
Valley Stream, New York, United States
Cincinnati Eye Institute
Cincinnati, Ohio, United States
Pro Scan Imaging
Mason, Ohio, United States
Associates in Ophthalmology, Ltd.
West Mifflin, Pennsylvania, United States
UPMC West Mifflin (MRI Only)
WestMifflin, Pennsylvania, United States
Hawthorne Pharmacy
Columbia, South Carolina, United States
InMed (MRI Facility)
Columbia, South Carolina, United States
Jay Markowitz, MD and Associates (Physical Exams Only)
West Columbia, South Carolina, United States
Palmetto Retina Center
West Columbia, South Carolina, United States
South Carolina Neurological Clinic (Neurological Exams Only)
West Columbia, South Carolina, United States
Centennial Medical Center (MRI Only)
Nashville, Tennessee, United States
Tennessee Retina, P.C
Nashville, Tennessee, United States
Radiology Associates of North Texas
Arlington, Texas, United States
Innovative Infusion
Arlington, Texas, United States
Texas Retina Associates
Arlington, Texas, United States
Kevin E. Conner
Arlington, Texas, United States
Radiology Associates of North Texas
Arlington, Texas, United States
Brian B. Berger, MD, PA
Austin, Texas, United States
Retina Research Center
Austin, Texas, United States
River Ranch Radiology
Austin, Texas, United States
Sleep Medicine Consultants
Austin, Texas, United States
Specialty Compounding
Cedar Park, Texas, United States
Advanced Radiology Services
Edinburg, Texas, United States
Edinburg Family Pharmacy
Edinburg, Texas, United States
McAllen Advanced Medical Imaging
McAllen, Texas, United States
McAllen Surgical Specialty Center
McAllen, Texas, United States
Tommy Yee MD
McAllen, Texas, United States
Valley Retina Institute,P.A.
McAllen, Texas, United States
Weslaco Advanced Imaging
Weslaco, Texas, United States
Proliance Surgeons, Inc. PS DBA Vitreo Retinal Associates
Bellevue, Washington, United States
Sound Prescriptions LLC
Bellevue, Washington, United States
Orthopedic Physician Assoc. - MRI
Seattle, Washington, United States
Proliance Surgeons, Inc. PS DBA Vitreo Retinal Associates
Seattle, Washington, United States
Countries
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Related Links
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To obtain contact information for a study center near you, click here.
Other Identifiers
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2012-000823-42
Identifier Type: EUDRACT_NUMBER
Identifier Source: secondary_id
B1181003
Identifier Type: -
Identifier Source: org_study_id
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