A Study of Disease Progression in Participants With Geographic Atrophy Secondary to Age-Related Macular Degeneration
NCT ID: NCT02479386
Last Updated: 2019-08-20
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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TERMINATED
296 participants
OBSERVATIONAL
2015-06-24
2018-01-31
Brief Summary
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Detailed Description
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Conditions
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Study Groups
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Cohort Geographic Atrophy
Cohort of participants with GA secondary to AMD will be evaluated for changes in GA over time.
No intervention
No intervention was administered in this study.
Interventions
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No intervention
No intervention was administered in this study.
Eligibility Criteria
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Inclusion Criteria
* The study is being conducted in participants with GA in both Study Eye and Non-Study Eye (bilateral GA) with no evidence of prior or active choroidal neovascularization (CNV)
Exclusion Criteria
* GA in either eye due to causes other than AMD
* History of vitrectomy surgery, submacular surgery, or any surgical intervention for AMD
* Previous laser photocoagulation for CNV, diabetic macular edema, retinal vein occlusion, and/or proliferative diabetic retinopathy
* Any ocular or systemic medical conditions that, in the opinion of the investigator, could contribute to participant's inability to participate in the study or interfere with study assessments
* Requirement for continuous use of therapy indicated in Prohibited Therapy in the study Protocol
50 Years
ALL
No
Sponsors
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Hoffmann-La Roche
INDUSTRY
Responsible Party
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Principal Investigators
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Clinical Trials
Role: STUDY_DIRECTOR
Hoffmann-La Roche
Locations
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Northwest Arkansas Retina Associates
Springdale, Arkansas, United States
Retinal Diagnostic Center
Campbell, California, United States
Specialty Eye Care Medical Center
Glendale, California, United States
Jules Stein Eye Institute/ UCLA
Los Angeles, California, United States
East Bay Retina Consultants
Oakland, California, United States
Colorado Retina Associates, PC
Golden, Colorado, United States
Rand Eye
Deerfield Beach, Florida, United States
Bascom Palmer Eye Institute
Naples, Florida, United States
Center For Sight
Sarasota, Florida, United States
Rush University Medical Center
Chicago, Illinois, United States
Paducah Retinal Center
Paducah, Kentucky, United States
Greater Baltimore Medical Center
Baltimore, Maryland, United States
Foundation for Vision Research
Grand Rapids, Michigan, United States
MaculaCare, PLLC
New York, New York, United States
Vitreous-Retina-Macula
New York, New York, United States
University of North Carolina; Kittner Eye Center
Chapel Hill, North Carolina, United States
Char Eye Ear &Throat Assoc
Charlotte, North Carolina, United States
Duke University Eye Center; Vitreoretinal
Durham, North Carolina, United States
Scheie Eye Institute
Philadelphia, Pennsylvania, United States
Palmetto Retina Center
Florence, South Carolina, United States
Retina Consultants of Houston
Houston, Texas, United States
Med Center Ophthalmology Assoc
San Antonio, Texas, United States
Wagner Macula & Retina Center
Norfolk, Virginia, United States
Organizacion Medica de Investigacion
Buenos Aires, , Argentina
Oftalmos
Capital Federal, , Argentina
Centro Privado de Ojos Romagosa
Córdoba, , Argentina
Onnis Instituto oftalmológico privado
Córdoba, , Argentina
Clinica Privada de Ojos
Mar del Plata, , Argentina
Centro Oftalmólogos Especialistas
Rosario, , Argentina
Northern Beaches Retina Cataract Glaucoma
Mona Vale, New South Wales, Australia
Strathfield Retina Clinic
Strathfield, New South Wales, Australia
Newcastle Eye Hospital Research Foundation
Waratah, New South Wales, Australia
Royal Victorian Eye and Ear Hospital
East Melbourne, Victoria, Australia
The Lions Eye Institute
Nedlands, Western Australia, Australia
Medizinische Universität Wien; Universitätsklinik für Augenheilkunde und Optometrie
Vienna, , Austria
Hospital de Olhos de Aparecida - HOA
Aparecida de Goiânia, Goiás, Brazil
Instituto da Visão
Belo Horizonte, Minas Gerais, Brazil
Botelho Hospital da Visao
Blumenau, Santa Catarina, Brazil
Instituto da Visão IPEPO
São Paulo, São Paulo, Brazil
Hosp Clinicas da FMUSP
São Paulo, São Paulo, Brazil
Calgary Retina Consultants
Calgary, Alberta, Canada
Institut De L'Oeil Des Laurentides
Boisbriand, Quebec, Canada
Chi De Creteil; Ophtalmologie
Créteil, , France
Clinique de la Louviere - Nord retine; Maladie et chirurgie des Yeux
Lille, , France
Centre ophtalmologique Rabelais; Ophtalmologie
Lyon, , France
Centre Paradis Monticelli; Ophtalmologie
Marseille, , France
Hopital Lariboisiere; Ophtalmologie
Paris, , France
CHNO des Quinze Vingts; Ophtalmologie
Paris, , France
Fondation Rothschild; Ophtalmologie
Paris, , France
CHU Poitiers - CHR La Miletrie; Ophtalmologie
Poitiers, , France
Centres Ophtalmologique St Exupéry; Ophtalmologie
Saint-Cyr-sur-Loire, , France
Cabinet La Maison Rouge; Ophtalmologie
Strasbourg, , France
Universitatsklinikum Leipzig
Leipzig, , Germany
Klinikum rechts der Isar der TU München; Augenklinik
München, , Germany
Universitätsklinikum Tübingen
Tübingen, , Germany
University General Hospital of Heraklion; Department of Ophthalmology
Heraklion, , Greece
European Interbalkan Medical Center; Ophthalmology Dpt
Thessaloniki, , Greece
Bajcsy-Zsilinszky Hospital
Budapest, , Hungary
Magyar Honvedseg Egeszsegugyi Kozpont; Fázis I-es Klinikai Farmakológiai Vizsgálóhely
Budapest, , Hungary
Kenezy Gyula Korhaz; Szemeszet
Debrecen, , Hungary
Markusovszky Egyetemi Oktatokorhaz ; SZEMESZET
Szombathely, , Hungary
Soroka university medical center; Ophtalmology
Beersheba, , Israel
Rambam Health Care Campus
Haifa, , Israel
Hadassah MC; Ophtalmology
Jerusalem, , Israel
Meir Medical Center; Ophtalmology
Kfar Saba, , Israel
Rabin Medical Center
Petah Tikva, , Israel
Chaim Sheba Medical Center
Ramat Gan, , Israel
Kaplan Medical Center; Ophtalmology
Rehovot, , Israel
Tel Aviv Sourasky MC; Ophtalmology
Tel Aviv, , Israel
Università degli Studi di Napoli Federico II; Dipartimento di Scienze Oftalmologiche
Napoli, Campania, Italy
ASST FATEBENEFRATELLI SACCO; Oculistica (Sacco)
Milan, Lombardy, Italy
Università degli Studi dell'Insubria; Clinica Oculistica
Varese, Lombardy, Italy
Azienda Ospedaliero-Universitaria Careggi; S.O.D. Oculistica
Florence, Tuscany, Italy
Nuovo Ospedale S. Chiara - A.O.U.P Presidio Ospedaliero di Cisanello; U.O. Oculistica Universitaria
Pisa, Tuscany, Italy
Ospedale Classificato Equiparato Sacro Cuore - Don Calabria; Dipartimento Oculistica
Negrar - Verona, Veneto, Italy
Klinika Okulistyki Ogolnej w Lublinie
Lublin, , Poland
Pomorski Uniwersytet Medyczny w Szczecinie, Zaklad Patologii Ogolnej PUM"
Szczecin, , Poland
SPEKTRUM Osrodek Okulistyki Klinicznej
Wroclaw, , Poland
Institut de la Macula i la retina
Barcelona, , Spain
Hospital de la Santa Creu i Sant Pau; Servicio de Oftalmologia
Barcelona, , Spain
Hospital Universitario Virgen de la Macarena; Servicio de Oftalmologia
Seville, , Spain
Clinica Doctores Piñero; Oftalmologia
Seville, , Spain
Hospital Clinico Universitario de Valladolid; Servicio de oftalmologia
Valladolid, , Spain
Hospital Universitario Rio Hortega; Servicio de Oftalmologia
Valladolid, , Spain
Bristol Eye Hospital
Bristol, , United Kingdom
Kent & Canterbury Hospital
Canterbury, , United Kingdom
Hull and East Yorkshire Eye Hospital
Hull, , United Kingdom
John Radcliffe Hospital; Oxford Eye Hospital
Oxford, , United Kingdom
University Hospital Southampton NHS Foundation Trust
Southhampton, , United Kingdom
Sunderland Eye Infirmary
Sunderland, , United Kingdom
Pinderfields Hospital; Clinical Research Team, Rowan House
Wakefield, , United Kingdom
Countries
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References
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Salvi A, Cluceru J, Gao SS, Rabe C, Schiffman C, Yang Q, Lee AY, Keane PA, Sadda SR, Holz FG, Ferrara D, Anegondi N. Deep Learning to Predict the Future Growth of Geographic Atrophy from Fundus Autofluorescence. Ophthalmol Sci. 2024 Oct 23;5(2):100635. doi: 10.1016/j.xops.2024.100635. eCollection 2025 Mar-Apr.
Anegondi N, Steffen V, Sadda SR, Schmitz-Valckenberg S, Tufail A, Csaky K, Lad EM, Kaiser PK, Ferrara D, Chakravarthy U. Visual Loss in Geographic Atrophy: Learnings from the Lampalizumab Trials. Ophthalmology. 2025 Apr;132(4):420-430. doi: 10.1016/j.ophtha.2024.11.017. Epub 2024 Nov 23.
Cluceru J, Anegondi N, Gao SS, Lee AY, Lad EM, Chakravarthy U, Yang Q, Steffen V, Friesenhahn M, Rabe C, Ferrara D. Topographic Clinical Insights From Deep Learning-Based Geographic Atrophy Progression Prediction. Transl Vis Sci Technol. 2024 Aug 1;13(8):6. doi: 10.1167/tvst.13.8.6.
Spaide T, Jiang J, Patil J, Anegondi N, Steffen V, Kawczynski MG, Newton EM, Rabe C, Gao SS, Lee AY, Holz FG, Sadda S, Schmitz-Valckenberg S, Ferrara D. Geographic Atrophy Segmentation Using Multimodal Deep Learning. Transl Vis Sci Technol. 2023 Jul 3;12(7):10. doi: 10.1167/tvst.12.7.10.
Other Identifiers
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2014-003939-19
Identifier Type: EUDRACT_NUMBER
Identifier Source: secondary_id
GX29639
Identifier Type: OTHER
Identifier Source: secondary_id
GX29633
Identifier Type: -
Identifier Source: org_study_id
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