Lornoxicam vs. Paracetamol After Lower Abdominal Surgery
NCT ID: NCT01564680
Last Updated: 2012-03-28
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
PHASE4
60 participants
INTERVENTIONAL
2009-03-31
2011-03-31
Brief Summary
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Methods: Sixty patients scheduled for lower abdominal surgery under general anesthesia were randomly allocated to receive either isotonic saline (Control group), intravenous paracetamol 1 g every 6 h (Paracetamol group) or lornoxicam 16 mg then 8 mg after 12 h (Lornoxicam group). Additionally pain was treated postoperatively using morphine patient-controlled analgesia. Postoperative pain scores measured by the verbal pain score (VPS), morphine consumption and the incidence of side effects were measured at 1, 2, 4, 8, 12 and 24 hours postoperatively.
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
QUADRUPLE
Study Groups
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Lornoxicam
Lornoxicam 16 mg will be given at skin closure and 8 mg will be given 12 hours postoperatively
Lornoxicam
16 mg at skin closure and 8 mg 12 hours postoperative
Control
Patients will receive normal saline at skin closure, at 6, 12, 18 hours postoperatively.
placebo
normal saline
Paracetamol
1 gm of paracetamol will be given at skin closure, 6, 12, 18 hours postoperatively
Paracetamol
IV paracetamol infusion
Interventions
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placebo
normal saline
Paracetamol
IV paracetamol infusion
Lornoxicam
16 mg at skin closure and 8 mg 12 hours postoperative
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
* history of significant cardiac, pulmonary, renal, hepatic or hematological disease; chronic drug or alcohol abuse; hypersensitivity to any of the studied drugs; bronchial asthma; gastritis or peptic ulcer; and pregnancy
* patients who received any analgesic drug a day before surgery
18 Years
69 Years
ALL
No
Sponsors
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Imam Abdulrahman Bin Faisal University
OTHER
Responsible Party
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Principal Investigators
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Hany A Mowafi, MD
Role: PRINCIPAL_INVESTIGATOR
UD
Locations
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Dammam University, KFHU
Khobar, EP, Saudi Arabia
Countries
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References
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Mowafi HA, Elmakarim EA, Ismail S, Al-Mahdy M, El-Saflan AE, Elsaid AS. Intravenous lornoxicam is more effective than paracetamol as a supplemental analgesic after lower abdominal surgery: a randomized controlled trial. World J Surg. 2012 Sep;36(9):2039-44. doi: 10.1007/s00268-012-1649-2.
Other Identifiers
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#201021
Identifier Type: -
Identifier Source: org_study_id
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