Analgesia by Transversus Abdominis Plane Nerve Block in Patients Undergoing Liver Resection.

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

TERMINATED

Clinical Phase

NA

Total Enrollment

39 participants

Study Classification

INTERVENTIONAL

Study Start Date

2010-04-30

Study Completion Date

2015-02-28

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

The indications liver cancer surgery currently booming due to the increase in surgical techniques and instruments for a more secure resection of liver tissue with a significant reduction in bleeding or surgical complications. This allowed to expand surgical indications in the most fragile patients so assuming optimized anesthetic care.

So far, the technique of analgesia reference to this surgery remains administration of morphine analgesia via a device controlled by the patient (PCA) for epidural analgesia is against-indicated because of induced bleeding disorders by surgery.

Rafi then McDonnell in 2007 have described a new technique of loco regional anesthesia, the abdomen of the Transversus Abdominis Plane (TAP) nerve block(TAP), which allows selective anesthesia of the abdominal wall. But parietal pain related muscular and nervous sagging surgical approach represent a significant share of post operative pain.

This study proposes an evaluation of the abdomen transverse blocks in hepatectomy.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Transversus Abdominis Plane Blocks With Abdominoplasty

NCT01278264

Post Operative Pain

UNKNOWN PHASE4

Programmed Intermittent Bolus Infusion of Thoracic Paravertebral Block for Hepatectomy

NCT04304274

Paravertebral Block Hepatectomy Analgesia +1 more

COMPLETED NA

Effectiveness of Transverse Abdominus Plane Catheter Blocks to Patient-controlled Analgesia in Laparoscopic Colon Resections

NCT01592630

Colorectal Disorders Observation of Neuromuscular Block

WITHDRAWN PHASE3

Continuous Paravertebral Block on Postoperative Pain After Hepatectomy

NCT01691937

Right Lobe Hepatectomy

COMPLETED PHASE2

Novel Technique of Analgesia Following Open Liver Resection

NCT01960049

Postoperative Pain Liver Resection

COMPLETED PHASE4

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Liver Cancer, Adult

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

TRIPLE

Participants Caregivers Investigators

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

ropivacaïne chlorhydrate monohydrate

Group Type EXPERIMENTAL

RopivacaIne chlorhydrate

Intervention Type DRUG

3mg/kg injection Hour (H) 0, H12 ; H24, H36 ; H48

placebo

Group Type PLACEBO_COMPARATOR

Placebo

Intervention Type DRUG

injection Hour (H) 0, H12 ; H24, H36 ; H48

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

RopivacaIne chlorhydrate

3mg/kg injection Hour (H) 0, H12 ; H24, H36 ; H48

Intervention Type DRUG

Placebo

injection Hour (H) 0, H12 ; H24, H36 ; H48

Intervention Type DRUG

Other Intervention Names

Discover alternative or legacy names that may be used to describe the listed interventions across different sources.

3mg/kg NaCl 0,9%

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* hepatectomy or segmentectomy

Exclusion Criteria

* Sepsis uncontrolled current
* Overdose in anticoagulant during general anesthesia
* Thrombocytopenia \<50 g / dl
* Severe renal impairment: Cockcroft \<30 ml / min
* history of ventricular arrhythmia serious unexplained .\*
* Allergy to local anesthetics of the amide
* Contraindication to remifentanil and morphine
* Hypovolemia

Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No