Schistosomiasis Effect on Response to Vaccines, Anaemia and Nutritional Status of Children of Northern Senegal
NCT ID: NCT01553552
Last Updated: 2012-03-14
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
99 participants
OBSERVATIONAL
2011-10-31
2011-10-31
Brief Summary
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Detailed Description
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The investigators then stimulated whole blood of these children with various vaccine antigens to address their immune function and study the influence of schistosomiasis infectious state on their overall immune condition.
Aims of the study:
To evaluate the interaction between schistosomiasis and the nutritional status of children and their haemoglobinemia.
To evaluate the influence of schistosomiasis on children's specific immune response towards EPI vaccine antigens, the inflammatory status of children and nutritional serologic markers.
To compare schistosomiasis diagnostic tools (evaluation of circulating cathodic antigen (CCA) strip for diagnosis of urinary schistosomiasis in comparison with microscopy and urinary dipsticks)
To study prevalence of intestinal parasites such as Blastocystis hominis
Conditions
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Study Design
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CASE_CONTROL
CROSS_SECTIONAL
Study Groups
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Infected by Schistosoma haematobium
No interventions assigned to this group
Not infected by Schistosoma haematobium
No interventions assigned to this group
Eligibility Criteria
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Inclusion Criteria
* Age: between 6 and 10 years
Exclusion Criteria
* malaria episode
6 Years
10 Years
ALL
Yes
Sponsors
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Institut Pasteur de Lille
OTHER
University of Lille Nord de France
OTHER
Région Nord-Pas de Calais, France
OTHER
Centre d'Infection et d'Immunité de Lille
OTHER
Centre National de la Recherche Scientifique, France
OTHER
Institut National de la Santé Et de la Recherche Médicale, France
OTHER_GOV
Biomedical Research Center EPLS
OTHER
Responsible Party
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Principal Investigators
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Emmanuel Hermann, PhD A.Pr.
Role: STUDY_CHAIR
Biomedical Research Center EPLS
Lobna Gaayeb, VetMed
Role: STUDY_DIRECTOR
Biomedical Research Center EPLS
Modou Seck, MD
Role: PRINCIPAL_INVESTIGATOR
Biomedical Research Center EPLS
Locations
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Biomedical Research Center EPLS
Saint-Louis, SL, Senegal
Countries
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References
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Hermann E, Gaayeb L, Sow PS, Seck M, Sagna AB, Senghor S, Bandagny L, Brinkhuizen C, Delcroix-Genete D, Schacht AM, Riveau G. Sex-dependent interactions between leptin, wasting and humoral immunity in two ethnic communities of school-aged children differentially exposed to Schistosoma haematobium. Trans R Soc Trop Med Hyg. 2017 Oct 1;111(10):448-456. doi: 10.1093/trstmh/trx078.
Related Links
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EPLS website
Other Identifiers
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EPLS11-MS
Identifier Type: -
Identifier Source: org_study_id
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