Effect of Alprazolam on the Success of Inferior Alveolar Nerve (IAN) Block

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Clinical Phase

PHASE4

Total Enrollment

60 participants

Study Classification

INTERVENTIONAL

Study Start Date

2011-03-31

Study Completion Date

2012-02-29

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

The purpose of this prospective, randomized, double-blind, placebo-controlled study is to evaluate the effect of preoperative administration of alprazolam on the success of the IAN block for teeth with irreversible pulpitis.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Comparison of Preoperative Analgesics on the Efficacy of Inferior Alveolar Nerve Block.

NCT05488925

Symptomatic Irreversible Pulpitis

COMPLETED PHASE4

Role of Alprazolam in Management of Post Endodontic Pain After Single Visit Root Canal Treatment. To Compare Mean Pain Score Between Two Group of Participants Undergoing Post Operative Pain Management After Single Visit Root Canal Treatment: NSAIDs Alone and a Combination of NSAIDs and Alprazolam.

NCT07275710

Pain

NOT_YET_RECRUITING NA

Effectiveness of Premedication on the Success Rate of Inferior Alveolar Nerve Block

NCT05097768

Symptomatic Irreversible Pulpitis

COMPLETED NA

Evaluation of the Success Rate of Pulpal Anesthesia in Mandibular First Molar Following Infiltration of 4% Articaine Alone and as Supplemental Injection After Inferior Alveolar Nerve Block

NCT01593930

Pulpal Anesthesia

COMPLETED NA

Evaluating the Combined Effect of Oral Premedications on Inferior Alveolar Nerve Block Effectiveness

NCT07146997

Symptomatic Irreversible Pulpitis

COMPLETED PHASE3

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Sixty patients diagnosed with irreversible pulpitis of a mandibular molar randomly receive, in a double-blind manner, identical capsules of either 0.50 mg alprazolam or placebo 45 minutes before the administration of a conventional IAN block. Access is begun 15 minutes after completion of the IAN block, and all patients profound lip numbness. Success is defined as no or mild pain based on visual analog scale recordings during access preparation and initial instrumentation.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Inferior Alveolar Nerve Block Failure

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

QUADRUPLE

Participants Caregivers Investigators Outcome Assessors

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

alprazolam

Alprazolam is a short-acting anxiolytic of the benzodiazepine class of psychoactive drugs

Group Type EXPERIMENTAL

Alprazolam

Intervention Type DRUG

preoperative administration of an orally 0.50 mg single dose

placebo

placebo capsules were filled with starch

Group Type PLACEBO_COMPARATOR

placebo

Intervention Type DRUG

placebo capsules were filled with starch

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

Alprazolam

preoperative administration of an orally 0.50 mg single dose

Intervention Type DRUG

placebo

placebo capsules were filled with starch

Intervention Type DRUG

Other Intervention Names

Discover alternative or legacy names that may be used to describe the listed interventions across different sources.

xanax, Pfizer starch

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* patients with active pain in a mandibular molar
* prolonged response to cold testing with Endo-Frost cold spray
* Absence of any periapical radiolucency on radiographs
* a vital pulp while access cavity preparation
* ability to understand the use of pain scales.

Exclusion Criteria

* patients were having allergy and sensitivity to benzodiazepines
* pregnant and breast feeding patients
* patients who had taken sedation within 24 hours before the treatment
* having pain in more than one mandibular tooth
* unable to give informed consent

Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes