Magnesium Associated With Morphine for Cancer Pain Relief

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

40 participants

Study Classification

INTERVENTIONAL

Study Start Date

2011-01-31

Study Completion Date

2014-03-31

Brief Summary

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This study is an evaluation of the analgesic effect of magnesium associated with morphine in patients with cancer pain.

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Detailed Description

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The study is prospective, randomized, double-blind. The patients will be allocated into two groups. After approval by the Ethics Committee and signed informed consent, 40 patients, aged \> 18 years of both genders with cancer pain, will be studied.

The patients in group 1 (n = 20) will receive a dose of magnesium sulfate (65 mg) po twice daily. Patients in Group 2 (n = 20) will receive placebo twice a day. The Mg and placebo capsules are identical. Everyone will receive morphine as needed.

Will be recorded: tumor location, factors which worsen the pain, quality of pain. Pain intensity will be assessed by numerical scale from zero to 10 at T0 (first visit) and after 1, 2, 3. and 4wk.

The patient will note the intensity of pain and side effects at home. Functional performance assessment will bes done by the Karnofsky Performance Status Scale. Quality of life will be assessed by the QLQ-c30.

Conditions

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Cancer-related Problem/Condition

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Participants Investigators

Study Groups

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Magnesiun, pain relief, sugar pills

Magnesiun 75mg po each 12h pain relief Sugar pills po each 12h

Group Type OTHER

Magnesiun

Intervention Type DRUG

75mg pills; each 12h; 12wk

Interventions

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Magnesiun

75mg pills; each 12h; 12wk

Intervention Type DRUG

Other Intervention Names

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NMDA receptor antagonist

Eligibility Criteria

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Inclusion Criteria

* After approval by the Ethics Committee and signed informed consent,
* 40 patients, \> 18 years, with cancer pain, and taking morphine (third step of the analgesic ladder recommended by WHO) were studied