Phase II Early Behavioral Intervention in BMT w/ Sleep Disturbance-Assess QOL+Fatigue+Cognitive f(x)

NCT ID: NCT01536977

Last Updated: 2014-06-02

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

29 participants

Study Classification

INTERVENTIONAL

Study Start Date

2012-03-31

Study Completion Date

2013-09-30

Brief Summary

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This pilot clinical trial studies early brief behavioral intervention in treating sleep disturbance and improving quality of life in patients undergoing bone marrow transplant (BMT). A brief behavioral intervention may reduce symptoms of insomnia and fatigue and improve quality of life and cognitive function in patients undergoing BMT

Detailed Description

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PRIMARY OBJECTIVES:

I. To provide preliminary data on the feasibility and efficacy of brief behavioral treatment for insomnia (BBT-I) on insomnia in hematopoietic cell transplant (HCT) recipients.

SECONDARY OBJECTIVES:

I. To provide preliminary data on the influence of BBT-I on cancer-related fatigue (CRF) and cognitive status in BMT recipients.

II. To provide preliminary data on the influence of BBT-I on quality-of-life (QOL) in BMT recipients.

OUTLINE:

Patients complete the BBT-I, comprising the following modules: 1) "What to expect" in terms of fatigue and insomnia as it occurs with cancer and cancer treatment; 2) A review of the Spielman Model of insomnia; 3) A discussion (based on the Spielman Model) regarding how insomnia and fatigue may co-occur and interact in the context of cancer and cancer treatment; 4) An introduction to the concept and practice of Stimulus Control Therapy; 5) An introduction to Sleep Scheduling Specifically modified for cancer patients; 6) Sleep Compression; and 7) Concomitant Medications and Substance Use.

After completion of study treatment, patients are followed up at 1 month.

Conditions

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Cognition Disorders Fatigue Sleep Disorders Other Complications of Bone Marrow Transplant

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

SUPPORTIVE_CARE

Blinding Strategy

NONE

Study Groups

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Supportive care (BBT-I)

Patients complete the BBT-I, comprising the following modules: 1) "What to expect" in terms of fatigue and insomnia as it occurs with cancer and cancer treatment; 2) A review of the Spielman Model of insomnia; 3) A discussion (based on the Spielman Model) regarding how insomnia and fatigue may co-occur and interact in the context of cancer and cancer treatment; 4) An introduction to the concept and practice of Stimulus Control Therapy; 5) An introduction to Sleep Scheduling Specifically modified for cancer patients; 6) Sleep Compression; and 7) Concomitant Medications and Substance Use.

Group Type EXPERIMENTAL

quality-of-life assessment

Intervention Type OTHER

Ancillary studies

questionnaire administration

Intervention Type OTHER

Ancillary studies

management of therapy complications

Intervention Type BEHAVIORAL

Undergo BBT-I

cognitive assessment

Intervention Type BEHAVIORAL

Ancillary studies

educational intervention

Intervention Type BEHAVIORAL

Undergo BBT-I

Interventions

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quality-of-life assessment

Ancillary studies

Intervention Type OTHER

questionnaire administration

Ancillary studies

Intervention Type OTHER

management of therapy complications

Undergo BBT-I

Intervention Type BEHAVIORAL

cognitive assessment

Ancillary studies

Intervention Type BEHAVIORAL

educational intervention

Undergo BBT-I

Intervention Type BEHAVIORAL

Other Intervention Names

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quality of life assessment complications of therapy, management of intervention, educational

Eligibility Criteria

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Inclusion Criteria

* Patient is scheduled to receive bone marrow transplantation.
* Patient has a diagnosis of Non-Hodgkin's Lymphoma
* Patient is at least 21 years old
* Patient is able to understand written and spoken English
* has preferred sleep phase between 9:00 pm and 3:00 am and a habitual rise time between 4:00 am and 11:00 am
* Patient receives a score of 8 or more on the Insomnia Severity Index or takes sleep medications 3 times a week

Exclusion Criteria

* Has an unstable medical or psychiatric illness (Axis I - current or within the last 5 years)
* Existing cognitive disability
* Is currently pregnant or nursing
* Has a history of substance abuse or meets criteria for current alcohol abuse or dependence
* Has a self-reported history of chronic pre-existing insomnia, sleep apnea or RSL syndrome
Minimum Eligible Age

21 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Stanford University

OTHER

Sponsor Role lead

Responsible Party

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Oxana Palesh

Assistant Professor of Psychiatry and Behavioral Science

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Oxana Palesh

Role: PRINCIPAL_INVESTIGATOR

Stanford University

Locations

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Stanford University

Stanford, California, United States

Site Status

Countries

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United States

Other Identifiers

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NCI-2012-00117

Identifier Type: REGISTRY

Identifier Source: secondary_id

SU-11112011-8650

Identifier Type: OTHER

Identifier Source: secondary_id

BMT242

Identifier Type: -

Identifier Source: org_study_id

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