Total Joint Arthroplasty and Sleep

NCT ID: NCT03968939

Last Updated: 2024-07-16

Study Results

Results available

Outcome measurements, participant flow, baseline characteristics, and adverse events have been published for this study.

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE4

Total Enrollment

55 participants

Study Classification

INTERVENTIONAL

Study Start Date

2019-10-01

Study Completion Date

2022-05-22

Brief Summary

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To compare non-prescription sleep aids (low-dose diphenhydramine and melatonin) to sleep hygiene education for improving postoperative sleep quality after total joint arthroplasty.

Detailed Description

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Conditions

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Primary Total Hip Arthroplasty Primary Total Knee Arthroplasty

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Participants Investigators
1. Benadryl + Melatonin Group + Sleep Hygiene Education
2. Sleep Hygiene Education Group
3. Control group (Usual Care)

Study Groups

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Control group (Usual Care)

Control Group (Usual Care): Participants do not use any type of sleep education or non-prescription sleep medications to assist with getting a "good night's sleep".

Group Type NO_INTERVENTION

No interventions assigned to this group

Sleep Hygiene Education

Sleep Hygiene Education: Participants are provided a Sleep Hygiene Education Brochure containing information about getting a "good night's sleep."

Group Type ACTIVE_COMPARATOR

Sleep Hygiene Education

Intervention Type BEHAVIORAL

Brochure containing information about getting a "good night's sleep."

Over-the-counter sleep aids (25 mg Benadryl + 3mg melatonin)

Participants are given both:

1. Over-the-counter sleep aids:25 mg Diphenhydramine (Benadryl) and 3mg oral melatonin to be taken before bedtime;
2. and a Sleep Hygiene Education Brochure containing information about getting a "good night's sleep."

Group Type ACTIVE_COMPARATOR

Diphenhydramine (Benadryl)

Intervention Type DRUG

Oral Diphenhydramine (Benadryl), 25 mg

Melatonin

Intervention Type DIETARY_SUPPLEMENT

Oral Melatonin, 3 mg

Sleep Hygiene Education

Intervention Type BEHAVIORAL

Brochure containing information about getting a "good night's sleep."

Interventions

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Diphenhydramine (Benadryl)

Oral Diphenhydramine (Benadryl), 25 mg

Intervention Type DRUG

Melatonin

Oral Melatonin, 3 mg

Intervention Type DIETARY_SUPPLEMENT

Sleep Hygiene Education

Brochure containing information about getting a "good night's sleep."

Intervention Type BEHAVIORAL

Eligibility Criteria

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Inclusion Criteria

All patients undergoing elective primary total hip or knee arthroplasty

Exclusion Criteria

1. History of substance abuse
2. Workman's compensation patients
3. Revision joint replacement
4. History of prescription or over-the- counter sleep aid use
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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James A. Keeney

OTHER

Sponsor Role lead

Responsible Party

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James A. Keeney

Chief Adult Hip and Knee Reconstruction Service, Department of Orthopaedic Surgery, University of Missouri

Responsibility Role SPONSOR_INVESTIGATOR

Locations

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Vicki L Jones

Columbia, Missouri, United States

Site Status

Countries

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United States

Provided Documents

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Document Type: Study Protocol

View Document

Other Identifiers

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2013726

Identifier Type: -

Identifier Source: org_study_id

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