Effect of the Salbutamol on Mechanical Properties of Respiratory System

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

200 participants

Study Classification

INTERVENTIONAL

Study Start Date

2011-06-30

Study Completion Date

2012-09-30

Brief Summary

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The aim of this study is to assess the bronchodilator response of salbutamol on respiratory mechanics of healthy individuals, smokers and COPD with varying degrees of airway obstruction.

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Detailed Description

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Clinical evaluation will be conducted and anthropometric measurements, then the pulmonary function tests: forced oscillation technique (FOT), whole body plethysmography, spirometry and-administration of salbutamol aerosol for assessment of bronchodilator response. After 20 minutes, the individual will be evaluated again following the same sequence.

Conditions

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Smoking Airway Obstruction

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

NONE

Study Groups

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Salbutamol

Short-acting bronchodilator for use in humans released by the Ministry of Health, widely used worldwide for the treatment of chronic obstructive pulmonary disease.

Group Type EXPERIMENTAL

Salbutamol sulphate

Intervention Type DRUG

bronchodilator test, beta2-agonist, short-acting, six hours duration, 400 micrograms.

Interventions

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Salbutamol sulphate

bronchodilator test, beta2-agonist, short-acting, six hours duration, 400 micrograms.

Intervention Type DRUG

Other Intervention Names

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Aerogold GO/DRUGS/341/L LOTE: YR1070

Eligibility Criteria

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Inclusion Criteria

* healthy individuals, smokers and patients with chronic obstructive pulmonary disease.

Exclusion Criteria

* healthy subjects: no history of smoking respiratory infection and disease respiratory
* smokers and chronic obstructive pulmonary disease patients: asthma and other respiratory diseases.

Minimum Eligible Age

40 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes