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Vitamin D Inadequacy is Associated With Incidence of Type 2 Diabetes

NCT ID: NCT01508481

Last Updated: 2012-10-10

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

1500 participants

Study Classification

OBSERVATIONAL

Study Start Date

2007-01-31

Study Completion Date

2012-10-31

Brief Summary

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Emerging evidence suggests that vitamin D \[25-hydroxyvitamin D; 25(OH)D\] may play a role in the etiology of type 2 diabetes. Vitamin D levels are lower in those with type 2 diabetes and impaired glucose tolerance (IGT) compared with those with normal glucose tolerance (NGT). In addition, a few prospective studies have shown a significant inverse association of baseline serum 25(OH)D with incident diabetes. To date, however, the exact mechanisms through which vitamin D affects diabetes risk are not yet fully known, particularly whether vitamin D plays a role in insulin resistance (IR) and/or b-cell dysfunction, the main pathophysiological disorders underlying type 2 diabetes. So, the investigators plan to examine the prospective associations of baseline vitamin D \[25-hydroxyvitamin D; 25(OH)D\] with insulin resistance (IR), b-cell function, and glucose homeostasis in subjects at risk for type 2 diabetes.

Detailed Description

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Conditions

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Type 2 Diabetes

Keywords

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Vitamin D Diabetes pancreas beta cell function insulin resistance Deficiency of Vitamin D3

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Diabetes high risk group

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* one or more risk factors for diabetes, including:

* obesity
* hypertension
* dislipidemia
* a family history of diabetes

Exclusion Criteria

* previous diagnosed diabetes
* vitamin D supplement.
Minimum Eligible Age

30 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Seoul National University Bundang Hospital

OTHER

Sponsor Role lead

Responsible Party

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Soo Lim

Principal Investigator

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Soo Lim, MD, PHD

Role: PRINCIPAL_INVESTIGATOR

Seoul National University Bundang Hospital

Locations

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Seoul National University Bundang Hospital

Seongnam, , South Korea

Site Status

Countries

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South Korea

References

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Lim S, Kim MJ, Choi SH, Shin CS, Park KS, Jang HC, Billings LK, Meigs JB. Association of vitamin D deficiency with incidence of type 2 diabetes in high-risk Asian subjects. Am J Clin Nutr. 2013 Mar;97(3):524-30. doi: 10.3945/ajcn.112.048496. Epub 2013 Jan 30.

Reference Type DERIVED
PMID: 23364011 (View on PubMed)

Other Identifiers

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VitaminD_T2DM

Identifier Type: -

Identifier Source: org_study_id