Impact of Bean Polyphenols and Phytic Acid on Iron Absorption

NCT ID: NCT01472484

Last Updated: 2012-06-19

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: NA
• Total Enrollment: 20 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2011-12-31
• Study Completion Date: 2012-01-31

Brief Summary

Recently isolated low PA varieties (lpa) in wheat, rice, maize, barley and beans might have the potential to alleviate iron bioavailability problems associated with PA. These plants have normal phosphate levels, but reduced PA phosphate due to various modifications of the biosynthetic pathway of PA. So far lpa crops are in an early stage of development, most of them exhibiting reduced yield and seed germination. However, the lpa bean isolated by Campion and co-workers 2009 by chemical mutagenesis exhibited only 10 % of the native bean PA concentration without any defects in terms of growth and yield.

Crossing the lpa variety with bean varieties low in PP and high in iron might lead to the development of a variety which has the potential to improve the iron status of bean consuming populations.

The following study will evaluate the relative impact of PA and PP on iron absorption from beans by comparing iron absorption from four different bean varieties. Iron absorption from a bean with normal PA concentration and high PP concentration will be compared to iron absorption from a bean with normal PA and low PP concentration as well as to two lpa varieties, one with high and one with low PP concentration.

Conditions

Blood Iron Isotope Enrichment

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: CROSSOVER
• Primary Study Purpose: BASIC_SCIENCE
• Blinding Strategy: SINGLE

Study Groups

lpa with high polyphenol

Group Type: EXPERIMENTAL

586/8x87 brown

Intervention Type: OTHER

2 x 50 g

lpa with low polyphenol

Group Type: EXPERIMENTAL

586/8x87 white

Intervention Type: OTHER

2 x 50 g

control bean with low polyphenol

Group Type: EXPERIMENTAL

586/8

Intervention Type: OTHER

2 x 50 g

control bean with high polyphenol

Group Type: EXPERIMENTAL

BAT 881

Intervention Type: OTHER

2 x 50 g

Interventions

586/8x87 white

2 x 50 g

Intervention Type: OTHER

586/8x87 brown

2 x 50 g

Intervention Type: OTHER

BAT 881

2 x 50 g

Intervention Type: OTHER

586/8

2 x 50 g

Intervention Type: OTHER

Eligibility Criteria

Inclusion Criteria

• Non-pregnant, non-lactating women
• Between 18 and 40 years
• Below 65kg

Exclusion Criteria

• Metabolic, chronic and gastro-intestinal disease
• Long-term medication
• Blood donation within 6 month before the study

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 40 Years
• Eligible Sex: FEMALE
• Accepts Healthy Volunteers: Yes

Sponsors

Swiss Federal Institute of Technology

OTHER

Sponsor Role: lead

Responsible Party

Prof. Michael B. Zimmermann

Prof

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Richard Hurrell, Prof. Dr.

Role: PRINCIPAL_INVESTIGATOR

ETH Zürich

Locations

ETH

Zurich, Canton of Zurich, Switzerland

Countries

Switzerland

References

Petry N, Egli I, Campion B, Nielsen E, Hurrell R. Genetic reduction of phytate in common bean (Phaseolus vulgaris L.) seeds increases iron absorption in young women. J Nutr. 2013 Aug;143(8):1219-24. doi: 10.3945/jn.113.175067. Epub 2013 Jun 19.

Reference Type: DERIVED

PMID: 23784069 (View on PubMed)

Other Identifiers

lpa_586/8X87

Identifier Type: -

Identifier Source: org_study_id