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Closed Loop Ventilation Strategy in Intensive Care Unit (ICU) Patients

NCT ID: NCT01472302

Last Updated: 2014-03-06

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE4

Total Enrollment

229 participants

Study Classification

INTERVENTIONAL

Study Start Date

2012-04-30

Study Completion Date

2014-01-31

Brief Summary

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Adaptive support ventilation (ASV) is a closed loop ventilation mode that can act both like PCV and PSV automatically. Some studies suggest that ASV can reduce the weaning time in ICU patients. The investigators hypothesized that using ASV from the beginning of intubation can reduce the total duration of MV and LOS in the ICU when compared to conventional modes such as PCV+PSV

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Detailed Description

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Conditions

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Respiratory Failure All Intubated Patients

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

SINGLE

Participants

Study Groups

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ASV

Adaptive Support Ventilation

Group Type EXPERIMENTAL

Adaptive Support Ventilation

Intervention Type DEVICE

Ventilation protocol according to the patients ideal body weight

PCV

Pressure Controlled Ventilation

Group Type ACTIVE_COMPARATOR

Pressure Controlled Ventilation

Intervention Type DEVICE

Ventilation protocol (6-8 ml/kg tidal volume) according to our ICU

Interventions

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Adaptive Support Ventilation

Ventilation protocol according to the patients ideal body weight

Intervention Type DEVICE

Pressure Controlled Ventilation

Ventilation protocol (6-8 ml/kg tidal volume) according to our ICU

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* Intubated and mechanically ventilated ICU patients for more than 24 hours

Exclusion Criteria

* Patient with a tracheostomy
* Patients under home mechanical ventilation
Minimum Eligible Age

19 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Izmir Dr Suat Seren Chest Diseases and Surgery Education and Research Hospital

OTHER

Sponsor Role lead

Responsible Party

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Cenk Kirakli

Principal investigator, Director of ICU

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Cenk Kirakli, MD

Role: PRINCIPAL_INVESTIGATOR

Izmir Dr. Suat Seren Chest Diseases and Surgery Training Hospital

Locations

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Izmir Chest Diseases and Surgery Education and Research Hospital, Intensive Care Unit

Izmir, Yenisehir, Turkey (Türkiye)

Site Status

Countries

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Turkey (Türkiye)

References

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Kirakli C, Naz I, Ediboglu O, Tatar D, Budak A, Tellioglu E. A randomized controlled trial comparing the ventilation duration between adaptive support ventilation and pressure assist/control ventilation in medical patients in the ICU. Chest. 2015 Jun;147(6):1503-1509. doi: 10.1378/chest.14-2599.

Reference Type DERIVED
PMID: 25742308 (View on PubMed)

Other Identifiers

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IGCEAH-ICU 2

Identifier Type: -

Identifier Source: org_study_id

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