Efficacy Emollient on Xerosis in Children With Atopic Dermatitis

NCT ID: NCT01467362

Last Updated: 2013-02-21

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE3

Total Enrollment

251 participants

Study Classification

INTERVENTIONAL

Study Start Date

2011-11-30

Study Completion Date

2012-05-31

Brief Summary

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Atopic dermatitis is a frequent, chronic inflammatory disease influenced by local, immunological, genetic and environmental factors. Important symptoms of atopic dermatitis are dry skin, intense pruritus and impaired epidermal barrier function. Atopic dermatitis is associated with skin barrier dysfunction that facilitates an easier allergen penetration into the skin with an increased irritation and subsequent cutaneous inflammation. A lack of important stratum corneum intercellular lipids and an inadequate ratio between compounds enhance trans-epidermal water loss leading to xerosis. Skin hydration by emollient therapy usually twice daily improves dryness and subsequently pruritus during the treatment of atopic dermatitis and especially improves the barrier function. Emollients make part of basic therapy (grade 1) for treatment of atopic dermatitis (European Academy of Dermatology and Venereology Task Force 2009 Position Paper). Improvement of cutaneous barrier alteration, measured by skin hydration, is a key element for evaluation of emollient treatment efficacy.

The primary objective of this study is to demonstrate the efficacy of the tested product (V0034CR01B) cream on xerosis in children with atopic dermatitis compared to the excipient formula during 28 days.

Detailed Description

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Conditions

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Atopic Dermatitis

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Participants Investigators

Study Groups

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V0034CR01B

Group Type EXPERIMENTAL

V0034CR01B

Intervention Type DRUG

Cream Out of flares: 1 application bid (morning and evening) During flares: 1 application once a day (in the morning) Maximum 91 days

desonide 0.1% cream

Intervention Type DRUG

cream, once a day (in the evening) during flares

Foaming gel

Intervention Type OTHER

for the washing and cleaning

Vehicle cream

Group Type PLACEBO_COMPARATOR

Vehicle cream

Intervention Type DRUG

Cream Out of flares: 1 application bid (morning and evening) During flares: 1 application once a day (in the morning) Maximum 28 days

desonide 0.1% cream

Intervention Type DRUG

cream, once a day (in the evening) during flares

Foaming gel

Intervention Type OTHER

for the washing and cleaning

Interventions

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V0034CR01B

Cream Out of flares: 1 application bid (morning and evening) During flares: 1 application once a day (in the morning) Maximum 91 days

Intervention Type DRUG

Vehicle cream

Cream Out of flares: 1 application bid (morning and evening) During flares: 1 application once a day (in the morning) Maximum 28 days

Intervention Type DRUG

desonide 0.1% cream

cream, once a day (in the evening) during flares

Intervention Type DRUG

Foaming gel

for the washing and cleaning

Intervention Type OTHER

Other Intervention Names

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Locapred Pediatril

Eligibility Criteria

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Inclusion Criteria

* Presenting with atopic dermatitis, dry skin, objective SCORAD \< 15,
* With xerosis on the body and a xerosis score \> = 2 (SCORAD sub-score) on the anterior part of lower limbs,

Exclusion Criteria

* Acute phase of atopic dermatitis
* Severe form of atopic dermatitis
Minimum Eligible Age

2 Years

Maximum Eligible Age

6 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Pierre Fabre Medicament

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Franck BORALEVI, Pr

Role: PRINCIPAL_INVESTIGATOR

Health centre

Locations

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Estonia

Tallinn, , Estonia

Site Status

Estonia

Tartu, , Estonia

Site Status

France

Bordeaux, , France

Site Status

France

Martigues, , France

Site Status

France

Nantes, , France

Site Status

France

Nice, , France

Site Status

France

Poitiers, , France

Site Status

Lithuania

Vilnius, , Lithuania

Site Status

Poland

Bialystok, , Poland

Site Status

Poland

Inowrocław, , Poland

Site Status

Poland

Lodz, , Poland

Site Status

Poland

Oleśnica, , Poland

Site Status

Poland

Poznan, , Poland

Site Status

Poland

Płock, , Poland

Site Status

Poland

Strzelce Opolskie, , Poland

Site Status

Poland

Warsaw, , Poland

Site Status

Poland

Żyrardów, , Poland

Site Status

Romania

Brasov, , Romania

Site Status

Romania

Bucharest, , Romania

Site Status

Romania

Constanța, , Romania

Site Status

Romania

Craiova, , Romania

Site Status

Romania

Iași, , Romania

Site Status

Romania

Ploieşti, , Romania

Site Status

Romania

Sibiu, , Romania

Site Status

Romania

Târgu Mureş, , Romania

Site Status

Countries

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Estonia France Lithuania Poland Romania

Other Identifiers

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2011-003295-37

Identifier Type: EUDRACT_NUMBER

Identifier Source: secondary_id

V00034 CR 3 12 1B

Identifier Type: -

Identifier Source: org_study_id

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