Efficacy Evaluation and Cutaneous Acceptibility of a Dermocosmetic Product on Subjects Suffering of Atopic Dermatisis.

NCT ID: NCT06756438

Last Updated: 2025-01-06

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

NA

Total Enrollment

88 participants

Study Classification

INTERVENTIONAL

Study Start Date

2024-09-02

Study Completion Date

2025-09-01

Brief Summary

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Atopic eczema is a chronic inflammatory skin disease, mainly affecting children, characterized by itching and flare-ups. It results from genetic and environmental factors, leading to immunological and cutaneous abnormalities.

The aim of this study is to assess the efficacy of a product for atopic skin versus a placebo. Primary objectives include assessing the number, the delay and severity of recurrences of atopic dermatitis (measured by the SCORAD score), and the evolution of symptoms such as dryness and pruritus. Secondary objectives include quality of life and quality of sleep and skin acceptability.

The study protocol is a multicenter, double-blind, randomized clinical trial, in which participants receive either the study product or a placebo, while continuing their topical corticosteroid treatment.

Detailed Description

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Conditions

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Atopic Dermatitis Eczema

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

This study was conducted under a double-blind, randomized, multicenter, before-and-after, parallel-group design. Participants received either the test product or a placebo, while continuing topical corticosteroid treatment in combination or as a relay.
Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Participants Investigators
Double-blind

Study Groups

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Amr 1: Study product

Product 1: Study product, Emollient. Face and body

Group Type EXPERIMENTAL

Study product

Intervention Type OTHER

Anti-itching, anti-replapse and repairing treatment. Emollient.

Arm 2: Placebo

Product 2: Placebo, Emollient. face and body

Group Type PLACEBO_COMPARATOR

Placebo

Intervention Type OTHER

Emollient

Interventions

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Study product

Anti-itching, anti-replapse and repairing treatment. Emollient.

Intervention Type OTHER

Placebo

Emollient

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

Specific

* Sex: female and/or male;
* Age: from 3 months up to 12 years old;
* Phototype: I to IV;
* 100% with atopic skin;
* 100% with sensitive skin;
* Subject who had at least 3 eczema flares-up of atopic dermatitis during the last 6 months before start of the study, including the crisis observed on D-X.
* Subject presenting on the visit D-X a flare-up of eczema for which the dermatologist prescribed treatment with topical corticosteroids treatment;
* Subjects with SCORAD between 15 and 40 on D-X;
* Subject who do not require medical treatment anymore after using prescribed topical corticosteroids from D-X up to D0 and clinical signs of atopic dermatitis are resolved, to be defined on D0 visit (in case of insufficient healing of inflammatory lesions, the subject continues medical treatment as recommended by the investigator).

General

* Healthy subject;
* Child whose at least one parent/legal guardian has given freely and expressly her/his informed consent;
* Child whose at least one parent/legal guardian is willing to adhere to the protocol and study procedures;
* Polish citizenship.

Exclusion Criteria

* Cutaneous pathology on the study zone other than atopic dermatitis;
* Use of topical or systemic treatment during the previous weeks liable to interfere with the assessment of the efficacy of the study products, including anti-histaminic treatment (except prescribed dermocorticoids on D-X and in case of flare-up during the study course);
* Subject having undergone a surgery under general anesthesia within the previous month;
* Excessive exposure to sunlight or UV-rays within the previous month;
* Subject enrolled in another clinical trial during the study period (concerns the studied zones);
* Subjects presenting oozing eczema lesions or any sign of infection on eczema lesions (e.g; pus).
Minimum Eligible Age

3 Months

Maximum Eligible Age

12 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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NAOS Les Laboratoires

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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EUROFINS

Gdansk, Poméranie, Poland

Site Status RECRUITING

Countries

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Poland

Central Contacts

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Wioleta MALINOWWSKA-KAKOL

Role: CONTACT

587320290

Facility Contacts

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Wioleta MALINOWSKA

Role: primary

+48 58 732 02 90

Other Identifiers

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RC2024PSaib+PL

Identifier Type: -

Identifier Source: org_study_id

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