Assessment of Skin Tolerance and Efficacy of a Cosmetic Product After 5 Days of Use on Subjects With Atopic Dermatitis

NCT ID: NCT05807113

Last Updated: 2023-04-11

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

44 participants

Study Classification

INTERVENTIONAL

Study Start Date

2022-02-15

Study Completion Date

2022-02-22

Brief Summary

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The aim of this study is to compare the efficacy and tolerability and of a cosmetic product to one that is already available on the market (benchmark product). Efficacy is assessed by instrumental measurements of skin condition, clinical examinations, and questionnaires.

Detailed Description

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The objective of this exploratory study is to investigate the efficacy and tolerability of a cosmetic product on subjects with atopic dermatitis after 5 days of use in comparison to a benchmark product.

The efficacy will be evaluated via instrumental measurements of skin hydration by Corneometer, transepidermal water loss by Tewameter and erythema by Chromameter as well as by evaluation of itch by using a Numerical Rating Scale (NRS). For efficacy and tolerability evaluation an objective and, in the case of adults, an additional subjective dermatological assessment will be performed.

Conditions

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Atopic Diathesis Eczema-prone Skin

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

intra-individual comparison
Primary Study Purpose

OTHER

Blinding Strategy

SINGLE

Participants

Study Groups

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Atopi intensive care BNO 3731 for topical use

Group Type EXPERIMENTAL

Atopi intensive care BNO 3731

Intervention Type OTHER

Crem twice daily

Benchmark skin care product for topical use

Group Type ACTIVE_COMPARATOR

Benchmark product

Intervention Type OTHER

Crem twice daily

Interventions

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Atopi intensive care BNO 3731

Crem twice daily

Intervention Type OTHER

Benchmark product

Crem twice daily

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Written Informed Consent of the subject to participate in the study, or, for underaged subjects of the parents/ legal guardians to let their child participate in the study
* Willingness to actively participate in the study and to come to the scheduled visits or, for underaged subjects, willingness of the parents/ legal guardians to actively support their child's participation in the study and to come to the scheduled visits with their child
* Female and/or male
* Children from 6 months to 14 years of age and Adult subjects between 18 and 65 years of age
* Eczema-prone skin and atopic diathesis, diagnosed by the dermatologist

Exclusion Criteria

* Female subjects: Pregnancy or lactation
* Drug addicts, alcoholics
* AIDS, HIV-positive or infectious hepatitis
* Conditions which exclude a participation or might influence the test reaction/evaluation
* Participation or being in the waiting period after participation in cosmetic and/or pharmaceutical studies pertaining to the test area
* Cancer not being diagnosed as cured and requiring chemotherapy, irradiation and/or hormonal treatment within the last 2 years
* Insulin-dependent diabetes mellitus
* One of the following illnesses with reduced physical capability/fitness: asthma (symptom-free allergic asthma is not an exclusion criterion), hypertension, cardiovascular diseases
* Documented allergies to cosmetic products and/ or ingredients, skin care and/or skin cleansing products
* Wounds, moles, tattoos, scars, excessive hair growth, etc. at the test area that could influence the investigation
* Systemic therapy with immuno-suppressive drugs (e.g. corticosteroids) and/or antihistamines (e.g. antiallergics) within the last 7 days prior to the start of the study
* Systemic therapy with anti-phlogistic agents or analgetics (e.g. diclophenac), except for minor pain relief medicine like acetylsalicylic acid or paracetamol within the last 3 days prior to the start of the study
Minimum Eligible Age

6 Months

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Bionorica SE

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Sabrina Laing, Dr.

Role: PRINCIPAL_INVESTIGATOR

proDERM GmbH

Locations

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SGS proderm GmbH

Schenefeld, , Germany

Site Status

Countries

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Germany

Other Identifiers

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CS02AC-ICBD

Identifier Type: -

Identifier Source: org_study_id

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