Study of 0416 Ointment in the Treatment of Atopic Dermatitis

NCT ID: NCT01053247

Last Updated: 2014-10-03

Study Results

Results available

Outcome measurements, participant flow, baseline characteristics, and adverse events have been published for this study.

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE3

Total Enrollment

793 participants

Study Classification

INTERVENTIONAL

Study Start Date

2008-01-31

Study Completion Date

2009-08-31

Brief Summary

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The aim of this trial is to assess the efficacy of 0416 Ointment in the Treatment of Atopic Dermatitis.

Treatment medication will be administered as follows: Apply a thin layer of ointment to affected skin areas twice daily and rub in gently and completely. Study medication will be applied twice a day, approximately 12 hours apart, for approximately 2 weeks.

Detailed Description

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Conditions

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Atopic Dermatitis

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

QUADRUPLE

Participants Caregivers Investigators Outcome Assessors

Study Groups

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Test

Test product that contains the active pharmaceutical ingredient

Group Type EXPERIMENTAL

0416

Intervention Type DRUG

Topical 0416 test product applied twice daily for 2 weeks

Reference

Reference product that contains active pharmaceutical ingredient

Group Type ACTIVE_COMPARATOR

tacrolimus ointment 0.1%

Intervention Type DRUG

Reference Product for 0416 test product. Apply twice daily for 2 weeks.

Vehicle

Placebo that contains no active pharmaceutical ingredient

Group Type PLACEBO_COMPARATOR

Vehicle of 0416 test product

Intervention Type DRUG

Vehicle of 0416 test product applied twice daily for 2 weeks

Interventions

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0416

Topical 0416 test product applied twice daily for 2 weeks

Intervention Type DRUG

Vehicle of 0416 test product

Vehicle of 0416 test product applied twice daily for 2 weeks

Intervention Type DRUG

tacrolimus ointment 0.1%

Reference Product for 0416 test product. Apply twice daily for 2 weeks.

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Clinical diagnosis of Atopic Dermatitis
* Good health with the exception of Atopic Dermatitis
* Percent Body Surface Area minimum requirements

Exclusion Criteria

* Subjects who are pregnant, nursing, or planning a pregnancy within the study participation period.
* Subjects who have any systemic or dermatological disorders with the exception of Atopic Dermatitis
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Fougera Pharmaceuticals Inc.

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Angela C Kaplan

Role: STUDY_DIRECTOR

Fougera Pharmaceuticals Inc.

Locations

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Fougera Pharmaceuticals Inc.

Melville, New York, United States

Site Status

Countries

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United States

Other Identifiers

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0416

Identifier Type: -

Identifier Source: org_study_id

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