The Role of Vitamin D Supplementation on Well Being and Symptoms of Depression During the Winter Season in Health Service Staff
NCT ID: NCT01462058
Last Updated: 2012-03-29
Study Results
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Basic Information
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COMPLETED
PHASE4
50 participants
INTERVENTIONAL
2011-10-31
2012-03-31
Brief Summary
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Detailed Description
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At higher latitudes ultraviolet B light is stopped by the atmosphere during winter season. Half of Danes have low levels of \[25(OH)D\] in the blood and especially in the early spring months the levels of \[25(OH)D\] are low. In addition, Vitamin D3 is absorbed through the gut from vitamin D-rich food sources. But several studies show that it is not possible through a recommended diet, which consists of 300 g of fish per week to consume adequate amounts of vitamin D3.
New research suggests link between vitamin D3 and brain function.In the Central Nervous System (CNS) there are specific nuclear receptors for 1,25(OH)2D (VDR) and the enzymes necessary for the hydroxylation of 25(OH)D to 1,25(OH)2D are also present in CNS.
In clinical studies, low serum levels of 25(OH)D, have been associated with reduced cognitive function, anxiety and depression.
The objective of this randomized clinical trial is to investigate whether indoor employees, with tendency to depressive symptoms in the winter season, should be offered vitamin D3 supplements during the Winter season, or it has no significance in relation prevent depressive symptoms.
The study is carried out in the winter season in the Region of Southern Denmark for 12 weeks and offered to health service staff, who have a tendency for depressive symptoms in the winter season.
Conditions
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Study Design
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RANDOMIZED
PARALLEL
PREVENTION
QUADRUPLE
Study Groups
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Vitamin D3
one tablet of vitamin D3 (70µg) per day for 12 weeks.
Vitamin D3
70µg Vitamin D3, daily, 12 weeks
placebo
one tablet of sugar pill per day for 12 weeks.
Placebo
Placebo, daily, 12 weeks
Interventions
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Vitamin D3
70µg Vitamin D3, daily, 12 weeks
Placebo
Placebo, daily, 12 weeks
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* Tendency to depressive symptoms in the winter season SPAQ\>7.
Exclusion Criteria
* tuberculosis
* bipolar affective disorder
* schizophrenia
* hypercalcemia
* hyperphosphatemia
* pregnancy
* hyperparathyroidism
* reduced kidney function
18 Years
65 Years
ALL
Yes
Sponsors
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Connie Thuree Nielsen, consultant, MD, ph.d
OTHER
Responsible Party
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Connie Thuree Nielsen, consultant, MD, ph.d
MD, ph.d
Locations
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Mental Health Services Esbjerg
Esbjerg, Esbjerg N, Denmark
Countries
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References
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Frandsen TB, Pareek M, Hansen JP, Nielsen CT. Vitamin D supplementation for treatment of seasonal affective symptoms in healthcare professionals: a double-blind randomised placebo-controlled trial. BMC Res Notes. 2014 Aug 14;7:528. doi: 10.1186/1756-0500-7-528.
Other Identifiers
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ID-301115
Identifier Type: -
Identifier Source: org_study_id
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