Molecular Mediators of Nerve Injury Signaling

NCT ID: NCT01437332

Last Updated: 2011-09-20

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

50 participants

Study Classification

OBSERVATIONAL

Study Start Date

2011-09-30

Brief Summary

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Specific proteins and other signaling molecules are increased and decreased following nerve injury. Some of these are important in producing pain or explaining why pain persists after traumatic nerve injuries or in disease states such as diabetes. In this study, the investigators hypothesize that it is possible to detect changes in specific signaling molecules and that these will provide insights into novel treatment strategies. The patients to be included are those who are undergoing the removal of tissue during surgery. The tissues that would otherwise be discarded will be included in the study as appropriate.

Detailed Description

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Conditions

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Diabetes Nerve Injury Chronic Neuropathic Pain

Study Design

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Observational Model Type

ECOLOGIC_OR_COMMUNITY

Study Time Perspective

PROSPECTIVE

Study Groups

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Diabetes

No interventions assigned to this group

Nerve injury

No interventions assigned to this group

Other

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* patients undergoing surgery where tissue removal is anticipated

Exclusion Criteria

* age younger than 18
Minimum Eligible Age

18 Years

Maximum Eligible Age

80 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Rambam Health Care Campus

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Rambam Health Care Campus

Haifa, , Israel

Site Status

Countries

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Israel

References

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Ebenezer GJ, McArthur JC, Thomas D, Murinson B, Hauer P, Polydefkis M, Griffin JW. Denervation of skin in neuropathies: the sequence of axonal and Schwann cell changes in skin biopsies. Brain. 2007 Oct;130(Pt 10):2703-14. doi: 10.1093/brain/awm199.

Reference Type BACKGROUND
PMID: 17898011 (View on PubMed)

Other Identifiers

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0356-11-RMB

Identifier Type: -

Identifier Source: org_study_id

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