Phase II Dose Titration Study in Patients With Neuropathic Pain

NCT ID: NCT00736151

Last Updated: 2009-08-07

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE2

Total Enrollment

272 participants

Study Classification

INTERVENTIONAL

Study Start Date

2004-05-31

Brief Summary

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The purpose of this study is to examine the effects of various increasing doses of Ralfinamide in patients with neuropathic pain.

Detailed Description

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Conditions

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Neuropathic Pain

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

DOUBLE

Study Groups

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1

Ralfinamide administered orally at rising doses of 80 - 320 mg/day

Group Type EXPERIMENTAL

Ralfinamide

Intervention Type DRUG

Oral tablets administered at rising doses of 80 - 320 mg/day

2

Placebo controlled with randomization of 2:1

Group Type ACTIVE_COMPARATOR

Ralfinamide

Intervention Type DRUG

Oral tablets administered at rising doses of 80 - 320 mg/day

Interventions

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Ralfinamide

Oral tablets administered at rising doses of 80 - 320 mg/day

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Male or female patients
* Females post-menopausal for at least 12 months, 24 months in India, Poland, and Austria
* Diagnosed by neurologist with current neuropathic pain
Minimum Eligible Age

18 Years

Maximum Eligible Age

85 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Newron Pharmaceuticals SPA

INDUSTRY

Sponsor Role lead

Responsible Party

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Newron Pharmaceuticals S.p.A

Locations

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Universitatsklinik Fur Neurologie

Graz, , Austria

Site Status

Universitatsklinik Fur Neurologie

Innsbruck, , Austria

Site Status

LKH

Klagenfurt, , Austria

Site Status

General Hospital AKH

Vienna, , Austria

Site Status

Fakultni nemocnice u svate' Anny v Brne

Brno, , Czechia

Site Status

Fakultni nemocnice Brno

Brno-Bhunice, , Czechia

Site Status

University Hospital Olomouc

Olomouc, , Czechia

Site Status

Univercity Hospital Pilsen

Pizen, , Czechia

Site Status

Fakultni Thomayerova nemocnices poliklinikou

Prague, , Czechia

Site Status

Na Homolce Hospital

Prague, , Czechia

Site Status

Neurology Centre

Ahmedabad, , India

Site Status

M.S. Ramaiah Medical

Bangalore, , India

Site Status

R.S. R'S Trinity Acute Care Hospital

Chennai, , India

Site Status

Sri Ramachandra medical College

Chennai, , India

Site Status

Care Hospital

Hyderabad, , India

Site Status

Chowpatty Medical Centre

Mumbai, , India

Site Status

Brain and Mind Institute

Nagpur, , India

Site Status

Apollo Hospital

Pradesh, , India

Site Status

Brain Waves Clinic

Pune, , India

Site Status

Vijaya Health Centre

Vadapalani, , India

Site Status

Ospedali Riuniti di Bergamo

Bergamo, , Italy

Site Status

Ce. S.I. Fondazione Universitaria

Chieti, , Italy

Site Status

Ospedale Clinicizzato Universitario SS. Annunziata

Chieti, , Italy

Site Status

Arcispedale Sant'Anna

Ferrara, , Italy

Site Status

Azienda Ospedaliera San Martino

Genova, , Italy

Site Status

Universita degli Studi di Genova

Genova, , Italy

Site Status

Ospedale Luigi Sacco

Grassi, , Italy

Site Status

Ospedale Civile Umberto I

Mestre, , Italy

Site Status

Ospedale San Raffaele

Milan, , Italy

Site Status

Istituto Scientifico di Riabilazione di Montescano

Montescano, , Italy

Site Status

Policlinico Universitario Federico II

Napoli, , Italy

Site Status

UCADH

Pavia, , Italy

Site Status

Presidio Ospedaliero Monteluce

Perugia, , Italy

Site Status

Universita degli Studi di Roma

Roma, , Italy

Site Status

Policlinico G.B. Rossi

Verona, , Italy

Site Status

Centrum Medyczne Osteomed

Bialobrzeska, , Poland

Site Status

Centrum Kliniczno Badawcze

Elblag, , Poland

Site Status

Wojewodzki Szpiyal Spejalistyczny

Gdansk, , Poland

Site Status

Center Of Clinical Neurology

Krakow, , Poland

Site Status

Osrodek Baden Klinicznych

Lublin, , Poland

Site Status

Wojskowy Instytut Medyczny

Warsaw, , Poland

Site Status

Wroclaw Medical University

Wroclaw, , Poland

Site Status

Oddzial Neurologiczny

Zgierz, , Poland

Site Status

Gartnavel General Hospital

Glasgow, , United Kingdom

Site Status

Barta and The London NHS Trust

London, , United Kingdom

Site Status

Kings College Hospital

London, , United Kingdom

Site Status

Solihull Hospital

West Midlands, , United Kingdom

Site Status

Countries

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Austria Czechia India Italy Poland United Kingdom

Other Identifiers

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NW-1029/001/II/2003

Identifier Type: -

Identifier Source: org_study_id

EUDRACT Number 2004-000557-35

Identifier Type: -

Identifier Source: secondary_id

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