Cortical Representation of Hyperalgesia Induced by Nerve Growth Factor

NCT ID: NCT02159170

Last Updated: 2015-01-16

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: NA
• Total Enrollment: 20 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2014-03-31
• Study Completion Date: 2014-12-31

Brief Summary

Intraepidermal injection of nerve growth factor results in a non-inflammatory hyperalgesia for thermal and mechanical stimuli. This hyperalgesia is similar to the pathological ailments of patients with neuropathic pain. The mechanisms of the cognitive modulation of pain and hyperalgesia are not yet understood in this group of patients. The investigators plan to use NGF injection as a model of non-inflammatory neuropathic pain in healthy subjects to investigate the underlying neuronal mechanisms of this hyperalgesia using functional magnetic resonance imaging and resting state network analysis.

Conditions

Non-inflammatory Neuropathic Pain; Healthy Subjects

Study Design

• Allocation Method: NA
• Intervention Model: SINGLE_GROUP
• Primary Study Purpose: BASIC_SCIENCE
• Blinding Strategy: NONE

Study Groups

NGF

injection of 50 µl NGF, once into the left volar forearm and injection of 50 µl NaCl (sodium chloride) once into the right volar forearm

Group Type: EXPERIMENTAL

NGF injection

Intervention Type: BIOLOGICAL

single injection of NGF into the volar forearm / single injection of NaCl into the volar forearm

Interventions

NGF injection

single injection of NGF into the volar forearm / single injection of NaCl into the volar forearm

Intervention Type: BIOLOGICAL

Eligibility Criteria

Inclusion Criteria

• no acute or chronic disease
• no acute or chronic pain
• age: 18-60 years
• male
• no medication use

Exclusion Criteria

• metallic parts in the body
• claustrophobia
• drug or substance abuse

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 60 Years
• Eligible Sex: MALE
• Accepts Healthy Volunteers: Yes

Sponsors

Heidelberg University

OTHER

Sponsor Role: collaborator

Prof Herta Flor

OTHER

Sponsor Role: lead

Responsible Party

Prof Herta Flor

Prof. Dr. Herta Flor

Responsibility Role: SPONSOR_INVESTIGATOR

Principal Investigators

Herta Flor, PhD

Role: PRINCIPAL_INVESTIGATOR

Medical Faculty Mannheim, Heidelberg University

Locations

Central Institute of Mental Health

Mannheim, , Germany

Countries

Germany

Other Identifiers

01ED1010D

Identifier Type: OTHER_GRANT

Identifier Source: secondary_id

LOGIN_NGF

Identifier Type: -

Identifier Source: org_study_id