Pain-related Evoked Potentials in Unilateral Peripheral Nerve Injuries

NCT ID: NCT03082820

Last Updated: 2017-03-21

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

64 participants

Study Classification

OBSERVATIONAL

Study Start Date

2015-02-03

Study Completion Date

2016-11-05

Brief Summary

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The study examines pain-related evoked potentials (PREP) in patients with peripheral nerve injuries. Since previous studies found altered latencies and amplitudes of PREP in generalized polyneuropathies, e. g. HIV-polyneuropathy and fibromyalgia, this study investigates if these alterations are detectable in unilateral peripheral nerve injuries as well.

Detailed Description

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Conditions

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Peripheral Nerve Injuries

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

CROSS_SECTIONAL

Study Groups

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Patients

Pain-related evoked potentials (PREP), Quantitative Sensory Testing (QST) and nerve conduction studies (NCS) were performed with patients with peripheral nerve injury.

Pain-related evoked potentials (PREP)

Intervention Type DIAGNOSTIC_TEST

PREP were performed bilaterally with a concentric surface electrode at twice the individual pain threshold.

Quantitative Sensory Testing (QST)

Intervention Type DIAGNOSTIC_TEST

QST was performed bilaterally following the protocol of the German Network on Neuropathic Pain.

Nerve conduction studies (NCS)

Intervention Type DIAGNOSTIC_TEST

NCS were performed with patients only.

Controls

Pain-related evoked potentials (PREP) and Quantitative Sensory Testing (QST) were performed with healthy adults.

Pain-related evoked potentials (PREP)

Intervention Type DIAGNOSTIC_TEST

PREP were performed bilaterally with a concentric surface electrode at twice the individual pain threshold.

Quantitative Sensory Testing (QST)

Intervention Type DIAGNOSTIC_TEST

QST was performed bilaterally following the protocol of the German Network on Neuropathic Pain.

Interventions

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Pain-related evoked potentials (PREP)

PREP were performed bilaterally with a concentric surface electrode at twice the individual pain threshold.

Intervention Type DIAGNOSTIC_TEST

Quantitative Sensory Testing (QST)

QST was performed bilaterally following the protocol of the German Network on Neuropathic Pain.

Intervention Type DIAGNOSTIC_TEST

Nerve conduction studies (NCS)

NCS were performed with patients only.

Intervention Type DIAGNOSTIC_TEST

Eligibility Criteria

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Inclusion Criteria

* Peripheral Nerve Injury

Exclusion Criteria

* Polyneuropathy
* Contralateral peripheral nerve injury
* Severe psychiatric disorders
* Disorders affecting central nervous system
Minimum Eligible Age

18 Years

Maximum Eligible Age

80 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Ruhr University of Bochum

OTHER

Sponsor Role lead

Responsible Party

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Christoph Maier, Prof. Dr.

Prof. Dr. med.

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Christoph Maier, Prof. Dr. med.

Role: STUDY_DIRECTOR

University Hospital Bergmannsheil Bochum

Other Identifiers

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PREP2015

Identifier Type: -

Identifier Source: org_study_id

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