Trial Investigating the Characteristics of Knismesis - a Lever to Explore Allodynia in Neuropathic Pain

NCT ID: NCT04621747

Last Updated: 2021-12-02

Basic Information

• Recruitment Status: UNKNOWN
• Clinical Phase: NA
• Total Enrollment: 24 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2021-11-23
• Study Completion Date: 2022-12-01

Brief Summary

Also known as a "moving itch", knismesis is a mildly annoying sensation caused by a light movement on the skin, such as from a crawling insect. Its underlying mechanism rely on spatial summation, i.e. amplification of the signal due to summation of stimulated fields, like it is for dynamic allodynia in neuropathic pain. This physiological study aims at determining the physical factors of the cutaneous stimulation inducing knismesis as well as the effect of confounding factors. The main area of exploration will be the back, because of its size and the possibility to blind the participant. The information collected, along with animal data in surrogate models, would help to better understand neuropathic pain in the future.

Detailed Description

This is a physiological proof-of-concept, also aiming to validate a functional exploration model in healthy volunteers. Each participant will undergo a battery if psychometric then psychophysics tests, presented sequentially. However, most of the main study tests (knismesis) will be admistered in a random order (crossover). The primary endpoint is to characterise, in the healthy human, the physical determinants of the cutaneous stimulation inducing knismesis: length of the pathway, speed, direction, intensity, continuity break of the contact, hairiness, body site, or distraction by other cutaneous stimuli. The secondary endpoint is to study the relationship between the individual sensitivity to spatial summation (knismesis) and other individual sensitivities or profiles.

Conditions

Healthy

Keywords

Neurophysiology; Psychophysics; Sensory thresholds; Neurons; Pain, neuropathic

Study Design

• Allocation Method: NA
• Intervention Model: SINGLE_GROUP
• Primary Study Purpose: BASIC_SCIENCE
• Blinding Strategy: NONE

Study Groups

Study group

healthy volunteers aged 18-35, balanced sex ratio, all of them undergoing the same battery of psychophysical explorations.

Group Type: EXPERIMENTAL

Battery of neurophysiological explorations

Intervention Type: OTHER

Visit 1: Biometry collection: gender, age, weight, height, eye colour.

• Questionnaires : the State and Trait Anxiety Inventory and the Pain Sensitivity
• Threshold of unpleasant light brightness, mechanical sensitivity threshold (von Frey hair).
• Training to estimate unpleasantness Under nociceptive and tickling stimuli, to use the handgrip.
• Mechanical pain threshold (electronic von Frey), heat pain threshold (Medoc Pathway).
• 48 stimulations applied to the back skin, following a predetermined plan with 12 different pathways, imbricated with 4 different speeds of movement.

Visit 2 (1 to 8 days later) :

• 42 stimulations applied to the back skin, to test the effect of stimulation intensity, the side of application, continuity break of the contact, and distraction by other cutaneous stimuli. The stimuli will follow the best paradigm as identified at the previous visit.
• 12 stimulations applied to forearm, cheeks, lower limbs, also testing the effect of hairiness.

Interventions

Battery of neurophysiological explorations

Visit 1: Biometry collection: gender, age, weight, height, eye colour.

• Questionnaires : the State and Trait Anxiety Inventory and the Pain Sensitivity
• Threshold of unpleasant light brightness, mechanical sensitivity threshold (von Frey hair).
• Training to estimate unpleasantness Under nociceptive and tickling stimuli, to use the handgrip.
• Mechanical pain threshold (electronic von Frey), heat pain threshold (Medoc Pathway).
• 48 stimulations applied to the back skin, following a predetermined plan with 12 different pathways, imbricated with 4 different speeds of movement.

Visit 2 (1 to 8 days later) :

• 42 stimulations applied to the back skin, to test the effect of stimulation intensity, the side of application, continuity break of the contact, and distraction by other cutaneous stimuli. The stimuli will follow the best paradigm as identified at the previous visit.
• 12 stimulations applied to forearm, cheeks, lower limbs, also testing the effect of hairiness.

Intervention Type: OTHER

Eligibility Criteria

Inclusion Criteria

• Ability to answer French questionnaires.

· BMI between 19 and 30 kg/m2 at inclusion.

Exclusion Criteria

• Pregnancy or breastfeeding.
• Natural intolerance to tickling.
• Any cutaneous, ocular or neurological disease contraindicating the psychophysical tests.
• Any disease or medical history that could expose the subject to unacceptable risk during the study.
• Any medication intake within 7 days before testing.
• History of drug or alcohol abuse.
• Involvement in another concomitant research protocol.
• Major dorsal hairiness.
• Inability to undergo the tests.
• Legal protection.
• Concomitant involvement in another clinical research.
• Refusal to participate.

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 50 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

NEURO-DOL (UMR 1107 INSERM / UCA)

UNKNOWN

Sponsor Role: collaborator

University Hospital, Clermont-Ferrand

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Locations

University Hospital, Clermont Ferrand

Clermont-Ferrand, Auvergne, France

Site Status: RECRUITING

Countries

France

Central Contacts

Lise Laclautre

Role: CONTACT

Phone: 0473754963

Email: promo_interne_drci@chu-clermontferrand.fr

Facility Contacts

lise laclautre

Role: primary

Other Identifiers

RBHP 2020 DUALE

Identifier Type: -

Identifier Source: org_study_id