Role of Adiponectin and Endothelial Progenitor Cells in Reperfusion Injury in Patients With Acute Myocardial Infarction

NCT ID: NCT01414452

Last Updated: 2015-07-21

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

250 participants

Study Classification

OBSERVATIONAL

Study Start Date

2011-04-30

Study Completion Date

2013-12-31

Brief Summary

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There is experimental evidence that low levels of adiponectin are associated with more reperfusion injury. In addition experimental studies have demonstrated that endothelial progenitor cells may have a favorable effect on remodeling, mainly through stimulation of neo-revascularisation. Clinical data on these issues are lacking. This clinical project studies the role of adiponectin, endothelial progenitor cells and endothelial microparticles in the ischaemia-reperfusion process and the compensatory ventricular remodelling in a population of 250 infarction patients treated with primary PCI. If the role of these factors could be confirmed in this clinical setting, those factors might represent a new target for therapeutic interventions in AMI patients.

Detailed Description

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Conditions

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Myocardial Infarction Reperfusion Injury

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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STEMI patients

Patients with ST elevation myocardial infarction,lasting \<12 hour, who were succesfully treated with primary PCI

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* STEMI treated with primary PCI

Exclusion Criteria

* ischemia time \>12h
* use of immunosuppressive therapy
* unsuccessful recanalisation
* not-interpretable ST-T segment
Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Universiteit Antwerpen

OTHER

Sponsor Role lead

Responsible Party

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M Claeys

Prof dr

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Marc Claeys, MD PHD

Role: PRINCIPAL_INVESTIGATOR

University Hospital, Antwerp

Locations

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University hospital

Edegem, Antwerp, Belgium

Site Status

Countries

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Belgium

Other Identifiers

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UAntwerpen

Identifier Type: -

Identifier Source: org_study_id

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