Role of Epicardial Adipose Tissue in Coronary Artery Disease

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

50 participants

Study Classification

OBSERVATIONAL

Study Start Date

2006-01-31

Study Completion Date

2006-12-31

Brief Summary

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We sight to evaluate whether patients with coronary artery disease (CAD) have more epicardial fat than patients without CAD, which would suggest that epicardial fat may be more than an "innocent bystander" and be actively involved in the disease process. Its role as a modulator of vascular response and myocardial function could potentially lead to new areas of cardiac research. We also sight to evaluate whether epicardial fat from patients with CAD releases more adipokines than subcutaneous fat from these patients which could prompt studies into the differential regulation of adipokine secretion in this tissue. Thus for e.g., the use of thiazolidinediones (glitazones), statins, ARBs or other compounds that can specifically modulate adipokine secretion could be explored to determine their benefit in ameliorating the effects attributable to increased epicardial fat.

Detailed Description

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Conditions

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Coronary Artery Disease Obesity

Keywords

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coronary artery disease epicardial adipose tissue epicardial fat obesity

Study Design

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Observational Model Type

DEFINED_POPULATION

Study Time Perspective

OTHER

Eligibility Criteria

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Inclusion Criteria

* All patients elegible for elective cardiac surgery are elegible
* Ability to provide written informed consent in accordance with GCP guidelines and local legislations.
* \> 18 years of age

Exclusion Criteria

* Control patients will not have clinical signs of CAD and will show normal coronary arteries on angiography.
* Any medical, social or geographic condition, which, in the opinion of the investigator would not allow safe or reliable completion of the protocol.

Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Principal Investigators

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Arya M Sharma, MD, FRCPC

Role: PRINCIPAL_INVESTIGATOR

McMaster University

Locations

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Hamilton Health Sciences - Cardiovascular Obesity Research and Management Center

Hamilton, Ontario, Canada

Site Status RECRUITING

Countries

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Canada

Central Contacts

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Suzana Damjanovic, MLT, CCRA

Role: CONTACT

Phone: 905-527-4322

Email: [email protected]

Other Identifiers

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EPICARD Study

Identifier Type: -

Identifier Source: org_study_id