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Characterization of Epicardial and Pericardial Adipose Tissue in Coronary Artery Disease

NCT ID: NCT02965625

Last Updated: 2020-11-27

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

28 participants

Study Classification

OBSERVATIONAL

Study Start Date

2016-10-31

Study Completion Date

2018-06-30

Brief Summary

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Human epicardial fat is the true visceral fat depot of the heart, and its regional distribution and physiology is of growing scientific and clinical interest. This study aims to characterize the expression profile and function of the epicardial and pericardial adipose tissue compartments of the heart (EAT and PAT). EAT and PAT adipose biopsies will be obtained from patients undergoing coronary artery bypass graft surgery (CABG) or valve replacement surgery.

Detailed Description

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The epicardial adipose tissue (EAT) stretches from the myocardium to the visceral layer of the pericardium. Adipose located on the outside of the visceral pericardium to the external site of the pericardium is called the pericardial adipose tissue (PAT), and is of a separate origin than EAT. Therefore, this study aims to investigate the global expression profile of the EAT and PAT compartments, in addition to characterizing the function, structure, metabolic and inflammatory profile. Furthermore, this study will determine whether CABG and valve replacement patients display different EAT and PAT characteristics

Conditions

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Coronary Artery Disease

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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open elective cardiac surgery patients

Including coronary artery bypass graft and valve replacement surgery patients

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* Age \<80 years
* Patients undergoing elective heart surgery either for coronary bypass grafting or for other purposes

Exclusion Criteria

* Inability of the patient to provide informed consent
* Severe kidney failure, GFR\<30
* Previous cardio-thoracic surgery
Minimum Eligible Age

18 Years

Maximum Eligible Age

80 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Copenhagen University Hospital, Denmark

OTHER

Sponsor Role collaborator

University of Copenhagen

OTHER

Sponsor Role collaborator

The Novo Nordisk Foundation Center for Basic Metabolic Research

OTHER

Sponsor Role collaborator

Rigshospitalet, Denmark

OTHER

Sponsor Role lead

Responsible Party

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Regitse Christensen

MD

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Regitse H Christensen, MD

Role: PRINCIPAL_INVESTIGATOR

Rigshospitalet, Denmark

Sarah E Heywood, PhD

Role: PRINCIPAL_INVESTIGATOR

Rigshospitalet, Denmark

Locations

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Centre for Physical Activity Research

Copenhagen, , Denmark

Site Status

Countries

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Denmark

Other Identifiers

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H-16031413

Identifier Type: -

Identifier Source: org_study_id