Disturbance of Water and Sodium Metabolism After Surgery of Sellar Lesions, and Correspond Clinical Strategy

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

UNKNOWN

Total Enrollment

350 participants

Study Classification

OBSERVATIONAL

Study Start Date

2011-02-28

Study Completion Date

2021-05-12

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

The fluid and electrolyte imbalance (FEI) is pretty common encountered during the clinical process of patients suffered sellar lesions. Moreover, if the patients are undergone the surgery for remove the lesion, FEI happens in all cases without exception. Hypo- and hyper-natremia is the most common electrolyte disorder, which is directly correlated to the patients' outcome. However, in clinical works, different sellar diseases cause variant features of FEI. For example, after the surgery of craniopharyngioma, the hyponatremia and hypernatremia always happen alternatively even without any precursor manifestation. Under this situation, it is quite difficult for fluid supplement. In contrast, the severe FEI will cause poor outcome, even death. So it is necessary to systematically collect and review the clinical data of sellar lesions. Through the analysis of variant FEI patterns of sellar diseases, more precise strategy for clinical fluid replacement will be proposed.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Effects of Intraoperative Goal-Directed Fluid Therapy on the Incidence of Postoperative Complications

NCT02507557

Postoperative Complications

UNKNOWN

Fluid Tonicity and Hyponatraemia Post Surgery

NCT03840629

Hyponatremia Surgery Fluid and Electrolyte Imbalance

COMPLETED

Prediction Models for Risk Score and Prognosis of Intraoperatively Acquired Pressure Injury in Surgical Patients

NCT06166641

Pressure Ulcer Predictive Models Surgical Patient +1 more

UNKNOWN

Colloid Infusion for Optimal Outcomes In Non-cardiac Surgery (COIN Trial)

NCT05728645

Postoperative Complications

ACTIVE_NOT_RECRUITING NA

Changes in Body Water During Surgery

NCT05272540

Postoperative Complications Bioelectrical Impedance Hospital Stay +1 more

COMPLETED

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

The Patients Suffered With Sellar Diseases The Fluid and Electrolyte Imbalance Happened After Surgery

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Observational Model Type

CASE_ONLY

Study Time Perspective

RETROSPECTIVE

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Diseases

1\. Pituitary adenomas; 2. Craniopharyngioma; 3. Sellar germinoma; 4. Sellar tuberalis meningioma; 5. Hypophystis; 6. Sellar glioma; 7. Rathke's cleft cyst; 8. Hypothalamic hamartoma

Chemical and physical detection

Intervention Type BIOLOGICAL

CVP, Urine volume per day, Blood electrolytes, Urine sodium per day, Pituitrin

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

Chemical and physical detection

CVP, Urine volume per day, Blood electrolytes, Urine sodium per day, Pituitrin

Intervention Type BIOLOGICAL

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* 1\. Suffered with sellar disease
* 2\. Udergone surgery
* 3\. Have sufficient presurgical and postsurgical clinical data (Including MRI, CT, physical and chemical detection results)