Postoperative Hyponatremia - Are There Gender Differences?
NCT ID: NCT00636857
Last Updated: 2013-06-12
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
NA
60 participants
INTERVENTIONAL
2008-03-31
2013-12-31
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
SINGLE
Study Groups
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I
Perioperative fluid management based on body weight
Fluid administration
Preoperative: bolus of 10 ml/kg body weight. During operation: 5 ml/kg body weight/hr. Postoperative: 3 ml/kg body weight/hr
II
Perioperative fluid management based on Lean Body Mass (LBM)
Perioperative fluid management based on Lean Body Mass
Preoperative: bolus of 12 ml/kg LBM. During operation: 6 ml/kg LBM/hr. Postoperative: 3.5 ml/kg LBM/hr
Interventions
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Fluid administration
Preoperative: bolus of 10 ml/kg body weight. During operation: 5 ml/kg body weight/hr. Postoperative: 3 ml/kg body weight/hr
Perioperative fluid management based on Lean Body Mass
Preoperative: bolus of 12 ml/kg LBM. During operation: 6 ml/kg LBM/hr. Postoperative: 3.5 ml/kg LBM/hr
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* Subjects scheduled for otorinolaryngoiatric surgery in general anesthesia of at least 3 hours duration
Exclusion Criteria
* BMI greater than 33
* Diabetes mellitus requiring medication
* Treatment with diuretics
* ACE-inhibitors
* Angiotensin II antagonists
* Cortisone
* Lithium
* Diseases of the kidney
* Females:
* Pregnancy
* Menopause
* Endocrine dysfunction influencing menstruation
18 Years
50 Years
ALL
No
Sponsors
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Karolinska University Hospital
OTHER
Responsible Party
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Vibeke Moen
Senior Consultant
Principal Investigators
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Johan Ullman, MD., PhD.
Role: PRINCIPAL_INVESTIGATOR
Dept of Anesthesia and Intensive Care, Karolinska University Hospital, Stockholm,
Locations
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Department of Anesthesia and Intensive Care, Karolinska University Hospital Huddinge
Stockholm, Stockholm County, Sweden
Dept of Anaesthesia and Intensive Care, Kalmar County Hospital
Kalmar, , Sweden
Department of Anaesthesia and Operation
Linköping, , Sweden
Dept. of Anesthesiology and Intensive Care, Karolinska University Hospital, Solna
Stockholm, , Sweden
Dept of Anaesthesia and Intensive Care, Uppsala University Hospital
Uppsala, , Sweden
Countries
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Central Contacts
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Facility Contacts
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Other Identifiers
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NKOISR10003
Identifier Type: -
Identifier Source: org_study_id
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