Study of Polymorphisms in pear1 Gene Link to Platelet Activation and Signaling Pathway Variations

NCT ID: NCT01352923

Last Updated: 2024-06-28

Basic Information

• Recruitment Status: WITHDRAWN
• Study Classification: OBSERVATIONAL
• Study Start Date: 2011-05-31
• Study Completion Date: 2012-05-31

Brief Summary

In this study PEAR1 polymorphisms effects will be analyze in blood platelets to determine how PEAR1 regulates platelet activation.

Detailed Description

Several large-scale studies have confirmed the long held notion that platelet responses to different agonists are highly variable, within well defined populations of healthy donors. Single nucleotide polymorphisms in genes encoding platelet proteins can explain the wide range of responses to standard platelet agonists. Yet, numerous SNPs point towards proteins with previously unknown function in platelets, wich modulate the complex network of signaling events that regulate platelet function and further augment variability. PEAR1 is mainly expressed in platelets and endothelial cells. A few studies have linked SNPs in PEAR1 with decreased or increased platelet responses to various agonists. However, hitherto, no direct functional studies have been carried out to determine whether and how PEAR1 modulate intracellular signaling pathways relevant for platelet function.

Conditions

Platelet Function

Study Groups

peripheral blood

healthy voluntary donors

blood test

Intervention Type: OTHER

preparation of blood platelets

Interventions

blood test

preparation of blood platelets

Intervention Type: OTHER

Eligibility Criteria

Inclusion Criteria

• healthy voluntary donors

Exclusion Criteria

• none

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 100 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

Universitaire Ziekenhuizen KU Leuven

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Marc Hoylaerts

Role: PRINCIPAL_INVESTIGATOR

KU Leuven

Locations

KUleuven/UZ Gasthuisberg

Leuven, Vlaams Brabant, Belgium

Countries

Belgium

Other Identifiers

B322201111373

Identifier Type: -

Identifier Source: org_study_id