a 3.0T Magnetic Resonance Imaging Study

NCT ID: NCT01346904

Last Updated: 2011-05-03

Basic Information

• Recruitment Status: UNKNOWN
• Total Enrollment: 200 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2011-05-31
• Study Completion Date: 2012-12-31

Brief Summary

Glaucomatous damage not only occurred to retinal ganglion cells in the eyes, but went across optic nerves, visual chiasm, lateral geniculate nucleus (LGN) and finally the visual cortex; the neural degenerations could be identified through the whole visual tract, which suggests the central nerve system may play a vital role in the progression of glaucoma. The investigators used MRI to investigate changes of visual pathway in vivo.

Conditions

Primary Open Angle Glaucoma

Study Design

• Observational Model Type: CASE_CONTROL
• Study Time Perspective: CROSS_SECTIONAL

Eligibility Criteria

Inclusion Criteria

• Primary open angle glaucoma diagnosed on the basis of glaucomatous optic disc cupping ratio (in particular, thinning of the inferior and/or superior rim, cup-to-disc ratio asymmetry of >0.2)
• matching glaucomatous visual field defects (European Glaucoma Society (2008) Perimetry )

Exclusion Criteria

• optic neuropathy
• neurological disorder
• other diseases and use of systemic medications which affect optic nerve or the visual field underwent complete eye examination and visual-field testing.

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

Sun Yat-sen University

OTHER

Sponsor Role: collaborator

Huazhong University of Science and Technology

OTHER

Sponsor Role: lead

Responsible Party

Department of Opthalmology ,Tongji Hospital

Principal Investigators

HONG ZHANG, PHD

Role: STUDY_CHAIR

Tongji Hospital

Other Identifiers

POAG3243

Identifier Type: -

Identifier Source: org_study_id