Efficacy Study of Nitazoxanide Suspension in the Treatment of Rotavirus Disease in Children

NCT ID: NCT01328925

Last Updated: 2011-04-05

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE2

Total Enrollment

100 participants

Study Classification

INTERVENTIONAL

Study Start Date

2005-12-31

Study Completion Date

2006-06-30

Brief Summary

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The purpose of this study is to determine the effectiveness of nitazoxanide suspension compared to placebo in treating rotavirus disease in pediatric patients less than 6 years of age.

Detailed Description

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Conditions

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Rotavirus Infection Viral Gastroenteritis Due to Rotavirus

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

QUADRUPLE

Participants Caregivers Investigators Outcome Assessors

Study Groups

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Nitazoxanide Oral Suspension

Nitazoxanide Oral Suspension 100 mg/5 ml

Group Type EXPERIMENTAL

Nitazoxanide

Intervention Type DRUG

Nitazoxanide Oral Suspension dose based on age:

Age \<12 months- 7.5 mg/kg by mouth twice daily for 3 days; Age 12-47 months- 100 mg/5 ml by mouth twice daily for 3 days; Age 48-72 months- 200 mg/10 ml by mouth twice daily for 3 days

Placebo Oral Suspension

Placebo Oral Suspension

Group Type PLACEBO_COMPARATOR

Nitazoxanide

Intervention Type DRUG

Nitazoxanide Oral Suspension dose based on age:

Age \<12 months- 7.5 mg/kg by mouth twice daily for 3 days; Age 12-47 months- 100 mg/5 ml by mouth twice daily for 3 days; Age 48-72 months- 200 mg/10 ml by mouth twice daily for 3 days

Interventions

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Nitazoxanide

Nitazoxanide Oral Suspension dose based on age:

Age \<12 months- 7.5 mg/kg by mouth twice daily for 3 days; Age 12-47 months- 100 mg/5 ml by mouth twice daily for 3 days; Age 48-72 months- 200 mg/10 ml by mouth twice daily for 3 days

Intervention Type DRUG

Other Intervention Names

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Alinia NTZ

Eligibility Criteria

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Inclusion Criteria

* Age \< 6 years.
* Patients with diarrhea (defined as 3 or more liquid stools per day).
* Stool positive for rotavirus by ELISA.

Exclusion Criteria

* Other identified causes of diarrhea at screening (pathogenic protozoa, bacteria, viruses or lactose intolerance).
* Serious systemic disorders incompatible with the study.
Maximum Eligible Age

5 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Romark Laboratories L.C.

INDUSTRY

Sponsor Role lead

Responsible Party

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Romark Laboratories, L.C.

Principal Investigators

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Mona Abu-Zekry, MD

Role: PRINCIPAL_INVESTIGATOR

Cairo University Children's Hospital

Locations

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Cairo University Children's Hospital

Cairo, , Egypt

Site Status

Countries

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Egypt

Other Identifiers

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RM02-3022

Identifier Type: -

Identifier Source: org_study_id

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