Phase III Placebo-controlled Study of V260 (RotaTeq™) in Japanese Healthy Infants (V260-029)(COMPLETED)

NCT ID: NCT00718237

Last Updated: 2017-04-13

Study Results

Results available

Outcome measurements, participant flow, baseline characteristics, and adverse events have been published for this study.

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE3

Total Enrollment

762 participants

Study Classification

INTERVENTIONAL

Study Start Date

2008-08-31

Study Completion Date

2009-08-31

Brief Summary

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The purpose of the study is to evaluate whether V260 is effective and well tolerated in Japanese healthy infants.

Detailed Description

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Conditions

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Rotavirus Gastroenteritis

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

PREVENTION

Blinding Strategy

DOUBLE

Participants Investigators

Study Groups

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1

RotaTeq™

Group Type EXPERIMENTAL

Rotavirus Vaccine, Live, Oral, Pentavalent (V260, RotaTeq™)

Intervention Type BIOLOGICAL

Rotateq orally administered 3 times

2

Placebo

Group Type PLACEBO_COMPARATOR

Comparator: Comparator: Placebo (unspecified)

Intervention Type BIOLOGICAL

Placebo orally administered 3 times

Interventions

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Rotavirus Vaccine, Live, Oral, Pentavalent (V260, RotaTeq™)

Rotateq orally administered 3 times

Intervention Type BIOLOGICAL

Comparator: Comparator: Placebo (unspecified)

Placebo orally administered 3 times

Intervention Type BIOLOGICAL

Other Intervention Names

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RotaTeq™ V260

Eligibility Criteria

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Inclusion Criteria

* Healthy Japanese Infants, 6 Weeks Through 12 Weeks Of Age

Exclusion Criteria

* History Of Known Prior Rotavirus Gastroenteritis
* Subjects Who Are Concurrently Participating In Or Are Anticipated To Participate In Other Studies Of Investigational Products At Any Time During The Study Period
Minimum Eligible Age

6 Weeks

Maximum Eligible Age

12 Weeks

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Merck Sharp & Dohme LLC

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Medical Monitor

Role: STUDY_DIRECTOR

Merck Sharp & Dohme LLC

References

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Iwata S, Nakata S, Ukae S, Koizumi Y, Morita Y, Kuroki H, Tanaka Y, Shizuya T, Schodel F, Brown ML, Lawrence J. Efficacy and safety of pentavalent rotavirus vaccine in Japan: a randomized, double-blind, placebo-controlled, multicenter trial. Hum Vaccin Immunother. 2013 Aug;9(8):1626-33. doi: 10.4161/hv.24846. Epub 2013 May 31.

Reference Type RESULT
PMID: 23732903 (View on PubMed)

Other Identifiers

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2008_014

Identifier Type: -

Identifier Source: secondary_id

V260-029

Identifier Type: -

Identifier Source: org_study_id

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