IBP-9414 for the Prevention of Necrotizing Enterocolitis

NCT ID: NCT02472769

Last Updated: 2017-12-29

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE2

Total Enrollment

120 participants

Study Classification

INTERVENTIONAL

Study Start Date

2016-05-27

Study Completion Date

2017-08-07

Brief Summary

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Two different dose levels will be evaluated in two different birth weight categories, compared to placebo with regards to safety and tolerability.

Detailed Description

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Conditions

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Necrotizing Enterocolitis

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

PREVENTION

Blinding Strategy

QUADRUPLE

Participants Caregivers Investigators Outcome Assessors

Study Groups

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IBP-9414

IBP-9414 Oral Daily

Group Type ACTIVE_COMPARATOR

IBP-9414

Intervention Type DRUG

Placebo

Sterile water

Group Type PLACEBO_COMPARATOR

Placebo

Intervention Type DRUG

Sterile water

Interventions

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IBP-9414

Intervention Type DRUG

Placebo

Sterile water

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

1. Gestational age ≤32 weeks
2. Birth weight: a) ≤ 2,000 g and b) ≤ 1,000 g.
3. \< 48 hours of age.
4. Written informed consent from the patient's legally authorized representative(s).

Exclusion Criteria

1. Participation in an additional interventional clinical trial in which an investigational drug will be administered.
2. Infants in extremis to whom no further intensive care is offered by attending neonatologist (e.g., infant being provided only hospice/comfort care).
3. Congenital or acquired gastrointestinal pathology.
4. Other conditions of the infant, which in the opinion of the attending neonatologist, preclude participation.
Maximum Eligible Age

48 Hours

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Infant Bacterial Therapeutics

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Josef Neu, MD

Role: PRINCIPAL_INVESTIGATOR

University of Florida College of Medicine, Gainsville, FL

Locations

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Univ. Arkansas Medical Sciences

Little Rock, Arkansas, United States

Site Status

UCLA Medical Center

Los Angeles, California, United States

Site Status

University Florida Health

Gainesville, Florida, United States

Site Status

Wolfson Children´s Hospital

Jacksonville, Florida, United States

Site Status

UF Health Jacksonville

Jacksonville, Florida, United States

Site Status

Jackson Memorial Hospital

Miami, Florida, United States

Site Status

Memorial Hospital of South Bend

South Bend, Indiana, United States

Site Status

Wesley Medical Center

Wichita, Kansas, United States

Site Status

Kings County Hospital Center

Brooklyn, New York, United States

Site Status

Duke University Medical Center

Durham, North Carolina, United States

Site Status

Wake Forest University Health Sciences

Winston-Salem, North Carolina, United States

Site Status

Hahnemann University Hospital

Philadelphia, Pennsylvania, United States

Site Status

Einstein Medical Center of Philadelphia

Philadelphia, Pennsylvania, United States

Site Status

Jackson Madison County General Hospital

Jackson, Tennessee, United States

Site Status

Timpanogos Regional Hospital

Orem, Utah, United States

Site Status

Countries

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United States

Other Identifiers

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IBP-9414-010

Identifier Type: -

Identifier Source: org_study_id