D-Ribose for Fatigue in Subjects With Fibromyalgia

NCT ID: NCT01315210

Last Updated: 2013-09-18

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE2

Total Enrollment

110 participants

Study Classification

INTERVENTIONAL

Study Start Date

2011-05-31

Study Completion Date

2012-10-31

Brief Summary

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To evaluate the safety and to determine the efficacy of D-ribose for the amelioration of fatigue in subjects with fibromyalgia. This is a phase IIa, randomized, double-blind, placebo-controlled, multi-center, multiple dose study of D-ribose versus placebo administered at doses of 5 g three times a day (TID) over a 12-week period to subjects who are experiencing fatigue associated with a diagnosis of fibromyalgia.

Detailed Description

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Conditions

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Fibromyalgia

Keywords

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Fibromyalgia Fatigue D-Ribose

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

QUADRUPLE

Participants Caregivers Investigators Outcome Assessors

Study Groups

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D-Ribose

Group Type EXPERIMENTAL

D-Ribose Powder

Intervention Type DRUG

5 g TID for 12 Weeks

Placebo

Group Type PLACEBO_COMPARATOR

Placebo Powder

Intervention Type DIETARY_SUPPLEMENT

5 g TID for 12 Weeks

Interventions

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D-Ribose Powder

5 g TID for 12 Weeks

Intervention Type DRUG

Placebo Powder

5 g TID for 12 Weeks

Intervention Type DIETARY_SUPPLEMENT

Eligibility Criteria

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Inclusion Criteria

* must have a diagnosis of primary fibromyalgia, as defined by the 1990 American College of Rheumatology (ACR) Criteria for the Classification of Fibromyalgia made at least 6 weeks prior to the Pretreatment Screening Visit;
* must have a score of ≥5 on the Subject's Assessment of Fatigue 11-point numerical rating scale (NRS) at the Pretreatment Screening and Baseline Visits;
* if taking acetaminophen or other non-opioid analgesics, NSAIDs, fibromyalgia medications, medications to induce sleep, or prednisone ≤ 10 mg (or equivalent dose of other glucocorticoids), must be on stable dose(s) for at least 4 weeks prior to the baseline visit;
* must have discontinued any ribose-containing products (including foods, drinks, and supplements) at least 4 weeks prior to the Pretreatment Baseline Visit.

Exclusion Criteria

* current major depressive episode (MDE);
* has been diagnosed with any autoimmune disease;
* has been diagnosed with type I or type II diabetes;
* has a history of cancer, other than basal cell carcinoma, stage 1 squamous cell carcinoma or cervical carcinoma in situ, that has not been in remission for at least five years prior to the Pretreatment Screening Visit;
* has been diagnosed with chronic fatigue syndrome.
Minimum Eligible Age

18 Years

Maximum Eligible Age

70 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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RiboCor, Inc.

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Leslie Crofford, MD

Role: PRINCIPAL_INVESTIGATOR

University of Kentucky

Locations

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Superior Research, LLC

Sacramento, California, United States

Site Status

Avail Clinical Research

DeLand, Florida, United States

Site Status

Renstar Medical Research

Ocala, Florida, United States

Site Status

University of Kentucky

Lexington, Kentucky, United States

Site Status

Columbia Medical Practice

Columbia, Maryland, United States

Site Status

The Center for Rheumatology and Bone Research

Wheaton, Maryland, United States

Site Status

Peters Medical Research

High Point, North Carolina, United States

Site Status

Wake Research Associates, LLC

Raleigh, North Carolina, United States

Site Status

Altoona Center for Clinical Research

Duncansville, Pennsylvania, United States

Site Status

Countries

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United States

Other Identifiers

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BIOE 02C 010

Identifier Type: -

Identifier Source: org_study_id