Study of Duloxetine Versus Placebo in the Treatment of Fibromyalgia Syndrome

NCT ID: NCT00190866

Last Updated: 2007-11-06

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE3

Total Enrollment

210 participants

Study Classification

INTERVENTIONAL

Study Start Date

2005-06-30

Study Completion Date

2007-06-30

Brief Summary

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To assess the efficacy of Duloxetine compared with placebo in the treatment of pain in patients with Fibromyalgia syndrome, with or without major depressive disorder.

Detailed Description

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Conditions

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Fibromyalgia

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Interventions

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Duloxetine

Intervention Type DRUG

placebo

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Meet criteria for primary Fibromyalgia Syndrome as defined by the American College of Rheumatology

Exclusion Criteria

* Have any current primary Axis I diagnosis other than major depressive disorder
* Have any current or previous diagnosis of psychosis, bipolar disorder, or schizoaffective disorder
* Have any primary diagnosis of anxiety disorder within the past year (including panic disorder, agoraphobia, OCD, PTSD, GAD and social phobia)
* Have regional pain syndrome, multiple surgeries or failed back syndrome
* Have a confirmed current or previous diagnosis of rheumatoid arthritis, inflammatory arthritis, or infective arthritis, or an autoimmune disease (e.g. lupus)
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Boehringer Ingelheim

INDUSTRY

Sponsor Role collaborator

Eli Lilly and Company

INDUSTRY

Sponsor Role lead

Principal Investigators

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Call 1-877-CTLILLY (1-877-285-4559) or 1-317-615-4559 Mon-Fri 9 AM - 5 PM Eastern time (UTC/GMT - 5 hours, EST)

Role: STUDY_DIRECTOR

Eli Lilly and Company

Locations

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For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon-Fri from 9AM to 5PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.

Peoria, Arizona, United States

Site Status

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Phoenix, Arizona, United States

Site Status

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Tucson, Arizona, United States

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Burbank, California, United States

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Sherman Oaks, California, United States

Site Status

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Walnut Creek, California, United States

Site Status

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Danbury, Connecticut, United States

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DeLand, Florida, United States

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Fort Myers, Florida, United States

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Miami, Florida, United States

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Lafayette, Indiana, United States

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Prairie Village, Kansas, United States

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Fall River, Massachusetts, United States

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Springfield, Massachusetts, United States

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St Louis, Missouri, United States

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Albany, New York, United States

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Greensboro, North Carolina, United States

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Cincinnati, Ohio, United States

Site Status

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Cleveland, Ohio, United States

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Toledo, Ohio, United States

Site Status

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Eugene, Oregon, United States

Site Status

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Portland, Oregon, United States

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Philadelphia, Pennsylvania, United States

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Wyomissing, Pennsylvania, United States

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Cranston, Rhode Island, United States

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Mt. Pleasant, South Carolina, United States

Site Status

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Myrtle Beach, South Carolina, United States

Site Status

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Austin, Texas, United States

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Lake Jackson, Texas, United States

Site Status

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San Antonio, Texas, United States

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Woodstock, Vermont, United States

Site Status

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Kirkland, Washington, United States

Site Status

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Seattle, Washington, United States

Site Status

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Ponce, , Puerto Rico

Site Status

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San Juan, , Puerto Rico

Site Status

Countries

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United States Puerto Rico

References

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Mease PJ, Spaeth M, Clauw DJ, Arnold LM, Bradley LA, Russell IJ, Kajdasz DK, Walker DJ, Chappell AS. Estimation of minimum clinically important difference for pain in fibromyalgia. Arthritis Care Res (Hoboken). 2011 Jun;63(6):821-6. doi: 10.1002/acr.20449.

Reference Type DERIVED
PMID: 21312349 (View on PubMed)

Russell JI, Mease PJ, Smith TR, Kajdasz DK, Wohlreich MM, Detke MJ, Walker DJ, Chappell AS, Arnold LM. Efficacy and safety of duloxetine for treatment of fibromyalgia in patients with or without major depressive disorder: Results from a 6-month, randomized, double-blind, placebo-controlled, fixed-dose trial. Pain. 2008 Jun;136(3):432-444. doi: 10.1016/j.pain.2008.02.024. Epub 2008 Apr 18.

Reference Type DERIVED
PMID: 18395345 (View on PubMed)

Other Identifiers

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F1J-MC-HMCJ

Identifier Type: -

Identifier Source: secondary_id

6222

Identifier Type: -

Identifier Source: org_study_id