Oral Antibiotic Treatment of Helicobacter Pylori Reduces Intestinal Colonization Rates With Oxalobacter Formigenes

NCT ID: NCT01300039

Last Updated: 2011-02-21

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

50 participants

Study Classification

OBSERVATIONAL

Study Start Date

2003-01-31

Study Completion Date

2008-06-30

Brief Summary

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The investigators are finding out if giving antibiotics for Helicobacter pylori will eliminate colonization of the colon by Oxalobacter formigenes.

Detailed Description

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Background and objectives: Oxalobacter formigenes (OF) may play a protective role in preventing calcium oxalate stones. Intestinal colonization by OF is associated with reduced urinary oxalate excretion. Exposure to antibiotics may be an important factor contributing to variable rates of colonization. This is the first prospective study to evaluate the effect of antibiotics on OF colonization.

Design, setting, participants, \& measurements: The effect of antibiotics on OF colonization was compared in 2 groups: a group receiving antibiotics for gastric infection with Helicobacter pylori (HP) and a group without HP that not receiving antibiotics. OF colonization in stool was detected by oxalate degradation at baseline and after 1 and 6 months.

Conditions

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Nephrolithiasis

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

PROSPECTIVE

Study Groups

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Antibiotics for H. pylori

Patients who underwent upper endoscopy and were found to have H. pylori, and were then to be treated with antibiotics for eradication of H. pylori

No interventions assigned to this group

Control group, no H. pylori

Patients who underwent upper endoscopy and found to not have H. pylori, and then would not receive antibiotics

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* age 18-80 years old
* undergoing upper endoscopy
* H. pylori present or absent on gastric histology
* stool positive for Oxalobacter formigenes

Exclusion Criteria

* unable to consent
* stool negative for Oxalobacter formigenes
Minimum Eligible Age

18 Years

Maximum Eligible Age

80 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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VA New York Harbor Healthcare System

FED

Sponsor Role lead

Responsible Party

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New York Harbor VA Medical Center

Principal Investigators

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David S Goldfarb, MD

Role: PRINCIPAL_INVESTIGATOR

New York Harbor VA Medical Center

Other Identifiers

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573

Identifier Type: -

Identifier Source: org_study_id

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