The Role of Cathepsin X in Infection With the Helicobacter Pylori

NCT ID: NCT01137942

Last Updated: 2010-07-12

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

14 participants

Study Classification

OBSERVATIONAL

Study Start Date

2008-11-30

Study Completion Date

2010-07-31

Brief Summary

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The immune response to Helicobacter pylori (Hp) importantly determines the pathogenesis of infection as well as the success of antibiotic eradication of the bacteria. The investigators want to demonstrate the importance of cathepsin X (CTSX), a cysteine protease, for the Hp eradication success. The diversity of the innate immune response to H. pylori antigens leading to either successful eradication of the infection or maintenance of chronic inflammation is connected to CTSX. The aim of this study is to determine whether H. pylori suppresses the CTSX expression and cytokine secretion in macrophage cell line THP-1 in the individuals that are not capable of eradicating the infection, opposite to H pylori in patients with successful H pylori eradication . The investigators also investigate the possibility whether strain-dependent differences in H. pylori lipopolysaccharide (LPS) influence the CTSX expression and cytokine secretion.

Detailed Description

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Conditions

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Persistence of Infection With Helicobacter Pylori

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

PROSPECTIVE

Study Groups

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H. pylori eradication failure

Those who eradicated Helicobacter pylori with appropriate antibiotic therapy and those who did not.

clarithromycin, metronidazole, proton pump inhibitor

Intervention Type DRUG

appropriate dose of antibiotics and proton pump inhibitor

Interventions

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clarithromycin, metronidazole, proton pump inhibitor

appropriate dose of antibiotics and proton pump inhibitor

Intervention Type DRUG

Other Intervention Names

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No other names

Eligibility Criteria

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Exclusion Criteria

\-
Minimum Eligible Age

18 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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University Medical Centre Ljubljana

OTHER

Sponsor Role lead

Responsible Party

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Institute of microbiology and immunology, Medical faculty Ljubljana, Slovenia

Principal Investigators

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Alojz Ihan, MD, PhD

Role: STUDY_DIRECTOR

Institute of microbiology and immunology, Ljubljana, Slovenia

Locations

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Abakus Medico

Rogaška Slatina, , Slovenia

Site Status RECRUITING

Countries

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Slovenia

Central Contacts

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Alojz Ihan, MD, PhD

Role: CONTACT

0038615437493

Miha Skvarc, MD

Role: CONTACT

0038615437484

Facility Contacts

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Bojan Tepes, MD. PhD

Role: primary

+386 (0) 3 819 14 11

Other Identifiers

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1000-05-310123

Identifier Type: OTHER_GRANT

Identifier Source: secondary_id

IMI2010-1

Identifier Type: -

Identifier Source: org_study_id

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