Procalcitonin as a Marker for the Length of Antibiotic Treatment in Peritonitis and Intra-abdominal Infections

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

162 participants

Study Classification

OBSERVATIONAL

Study Start Date

2009-06-30

Study Completion Date

2014-06-30

Brief Summary

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Procalcitonin level used for determining length of antibiotic treatment in peritonitis and intra-abdominal infections. Hypothesis is that length of antibiotic use can be shortened by this method.

Detailed Description

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Prospective randomized trial

Conditions

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Secondary or Tertiary Peritonitis

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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procalcitonine monitoring

PCT group: antibiotic use is tailored by serum procalcitonin values, determined every 48houres.

No interventions assigned to this group

control group

control group: antibiotic use and length of treatment as defined by guidelines

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* More than 18 yo
* Patient requiring surgery for peritonitis or intra-abdominal infection following: perforation, necrosis, previous operation...
* Mannheim Peritonitis score \> 14
* SIRS present
* Probability of survival \> 72h
* Informed consent by patient/relatives

Exclusion Criteria

* No SIRS
* Long date corticoid treatment
* Immunosuppression
* Thyroid medullary carcinoma
* Anaphylactic shock
* Acute hepatic deficiency

Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Responsible Party

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Nicolas DEMARTINES

professor of surgery

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Steve Aellen, MD

Role: PRINCIPAL_INVESTIGATOR

Department of visceral surgery, university hospital

Locations

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University Hospital of Lausanne

Lausanne, , Switzerland

Site Status

Countries

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Switzerland

Other Identifiers

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141/08, Propéritonite

Identifier Type: -

Identifier Source: org_study_id