Study of Cases of Serious Infections Due to Carbapenem-Resistant Enterobacteriaceae

NCT ID: NCT02420366

Last Updated: 2018-05-02

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Total Enrollment

257 participants

Study Classification

OBSERVATIONAL

Study Start Date

2014-05-31

Study Completion Date

2015-01-31

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

A multi-center, retrospective study of cases of serious bacterial infections including complicated Urinary Tract Infection (cUTI) or Acute Pyelonephritis (AP), Hospital Acquired Bacterial Pneumonia (HABP), Ventilator Acquired Bacterial Pneumonia (VABP), and/or bacteremia caused by Carbapenem-Resistant Enterobacteriaceae (CRE)

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

This multi-center, retrospective study of cases of serious bacterial infections (including cUTI or AP, HABP, VABP, and/or bacteremia caused by CRE) will consist of a chart review over a 6 month period from September 1, 2013 to March 1, 2014. De-identified data will be collected from the chart review of at least 150 cases of selected infections due to CRE at approximately 20 sites.

The study itself is strictly observational and retrospective, with no direct study-related patient interaction, treatment, or testing. There will be no patient identifying data collected as part of this study.

Charts of patients who meet study-defined criteria for cUTI or AP, HABP, VABP, and/or bacteremia and have a culture from the site of infection or the blood that is positive for a Carbapenem-Resistant Enterobacteriaceae will be reviewed.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Urinary Tract Infection, Complicated Acute Pyelonephritis Hospital Acquired Bacterial Pneumonia Ventilator-associated Bacterial Pneumonia Bacteremia

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Observational Model Type

CASE_ONLY

Study Time Perspective

RETROSPECTIVE

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* Male or female ≥18 years of age.
* Carbapenem resistant Enterobacteriaceae (CRE) must be identified in the urine, blood or respiratory tract samples submitted for culture in the setting of cUTI or AP, HABP, VABP, and/or bacteremia.
* Diagnosis with either cUTI or AP, HABP, VABP, and/or bacteremia.

Exclusion Criteria

* none
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

Meet the organizations funding or collaborating on the study and learn about their roles.

Rempex (a wholly owned subsidiary of Melinta Therapeutics, Inc.)

INDUSTRY

Sponsor Role lead

Responsible Party

Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.

Responsibility Role SPONSOR

Principal Investigators

Learn about the lead researchers overseeing the trial and their institutional affiliations.

Karen Fusaro

Role: STUDY_DIRECTOR

Sponsor GmbH

Locations

Explore where the study is taking place and check the recruitment status at each participating site.

Chicago, Illinois, United States

Site Status

Evanston, Illinois, United States

Site Status

Detroit, Michigan, United States

Site Status

New Brunswick, New Jersey, United States

Site Status

Somers Point, New Jersey, United States

Site Status

New York, New York, United States

Site Status

New York, New York, United States

Site Status

Rochester, New York, United States

Site Status

Durham, North Carolina, United States

Site Status

Cleveland, Ohio, United States

Site Status

Pittsburgh, Pennsylvania, United States

Site Status

Charlottesville, Virginia, United States

Site Status

Athens, , Greece

Site Status

Bologna, , Italy

Site Status

Florence, , Italy

Site Status

Genova, , Italy

Site Status

Pisa, , Italy

Site Status

Roma, , Italy

Site Status

Rome, , Italy

Site Status

Udine, , Italy

Site Status

Manchester, , United Kingdom

Site Status

Manchester, , United Kingdom

Site Status

Countries

Review the countries where the study has at least one active or historical site.

United States Greece Italy United Kingdom

Other Identifiers

Review additional registry numbers or institutional identifiers associated with this trial.

Rempex 506 NH

Identifier Type: -

Identifier Source: org_study_id

More Related Trials

Additional clinical trials that may be relevant based on similarity analysis.

Ertapenem in Patients With Urosepsis
NCT03859362 UNKNOWN PHASE4