Effect of Short-term Chinese Tea-flavor Liquor Consumption

NCT ID: NCT01294995

Last Updated: 2011-02-14

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: PHASE1
• Total Enrollment: 45 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2010-10-31
• Study Completion Date: 2010-11-30

Brief Summary

Human studies of Chinese liquor are sparse. The investigators hypothesize that short-term Chinese Tea-flavor liquor (TFL) consumption may be beneficial to inflammation biomarkers and CVD risk factors. Guizhou Meijiao Liquor (GML) is a traditional Chinese liquor, fermented from sorghum, corn, sticky rice, wheat and rice, while TFL is a novel Chinese liquor fermented from above 5 grains plus green tea.

Forty-five volunteers(23 males, 22 females) were selected to participate a paralleled randomized trial drinking 30 mL two kinds of Chinese liquors: TFL and GML respectively with meal every day for 28 days. Serums of volunteers were collected for analyzing serum lipids, inflammation biomarkers and CVD risk factors.

TFL could significantly decrease systolic blood pressure of males, but increase diastolic blood pressure of females. TFL could also decreased blood lipid of volunteers, especially for females. Both liquor significantly decrease serum uric acid and glucose in males and females. The effect of the two liquors on inflammation biomarkers were complicated and needs further research work.

TFL may possess more beneficial effect on CVD risk factors than GML probably because of the special fermentation products of green tea with other grains.

Conditions

Cardiovascular Diseases

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Study Groups

Tea-flavor Liquor, taken with meal

including 12 males and 11 females

Group Type: EXPERIMENTAL

Tea-flavor Liquor

Intervention Type: DIETARY_SUPPLEMENT

30 mL of Tea-flavor Liquor(45% alcohol content)

Guizhou Meijiao Liquor, taken with meal

including 11 males and 11 females

Group Type: PLACEBO_COMPARATOR

Guizhou Meijiao Liquor

Intervention Type: DIETARY_SUPPLEMENT

30 mL of Guizhou Meijiao Liquor (45% alcohol content)

Interventions

Tea-flavor Liquor

30 mL of Tea-flavor Liquor(45% alcohol content)

Intervention Type: DIETARY_SUPPLEMENT

Guizhou Meijiao Liquor

30 mL of Guizhou Meijiao Liquor (45% alcohol content)

Intervention Type: DIETARY_SUPPLEMENT

Eligibility Criteria

Inclusion Criteria

• Healthy male and female volunteers

Exclusion Criteria

• Subjects with a history of liver disease, diabetes, or heart disease
• Smokers

• Minimum Eligible Age: 23 Years
• Maximum Eligible Age: 28 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

Guizhou Meijiao Co., Ltd

UNKNOWN

Sponsor Role: collaborator

Zhejiang University

OTHER

Sponsor Role: lead

Responsible Party

Department of Food Science and Nutrition

Locations

Department of food science and nutrition

Hangzhou, Zhejiang, China

Countries

China

Other Identifiers

ST Chinese liquor study

Identifier Type: -

Identifier Source: org_study_id