Influence of Acid Reflux on Stromal Epithelial Interaction in Barrett's Esophagus
NCT ID: NCT01281618
Last Updated: 2013-05-06
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
48 participants
OBSERVATIONAL
2008-10-31
2011-06-30
Brief Summary
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Specific aim 1: To test the hypothesis that controlled acid reflux is associated with lesser degree of stromal activation.
Specific aim 2: To test the hypothesis that stromal fibroblast derived growth factors drive BE epithelial proliferation.
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Detailed Description
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Conditions
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Study Design
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CASE_ONLY
PROSPECTIVE
Study Groups
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Those with barrett's esophagus
Those with barrett's esophagus: no dysplasia or low grade dysplasia
24 hour pH study and upper endoscopy (EGD)
All subjects enrolled will undergo 24 hour pH followed by EGD.
Interventions
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24 hour pH study and upper endoscopy (EGD)
All subjects enrolled will undergo 24 hour pH followed by EGD.
Eligibility Criteria
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Inclusion Criteria
2. Absence of dysplasia or LGD on biopsies within the past 5 years
3. Ability to provide informed consent
4. Age between 18 years and 90 years at study entry.
Exclusion Criteria
2. Inability to tolerate endoscopic procedures
3. Pregnancy: Females of child-bearing age will be screened with pregnancy test.
4. Prior esophageal surgery, or cancer
18 Years
90 Years
ALL
No
Sponsors
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National Institutes of Health (NIH)
NIH
Mayo Clinic
OTHER
Responsible Party
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Prasad G. Iyer
MD
Locations
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Mayo Clinic
Rochester, Minnesota, United States
Countries
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Other Identifiers
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07-004899
Identifier Type: -
Identifier Source: org_study_id
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