MedDataX Logo

Functional and Molecular Characterisation of Oesophageal Distal Epithelium: Correlations With Acid and Non Acid Reflux

NCT ID: NCT00231881

Last Updated: 2007-04-30

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

UNKNOWN

Total Enrollment

60 participants

Study Classification

OBSERVATIONAL

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

This study aims to characterize the permeability as well as some protein involved in the cell junction in the oesophageal epithelium in patients with GORD symptoms. In addition these patients will be characterized for their reflux especially by pH-impedancemetry, Bilitec and oesophageal acid perfusion test. Correlations between the characteristics of the reflux and the biological results will be calculated.

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

This study aims to characterize the permeability as well as some protein involved in the cell junction in the oesophageal epithelium in patients with GORD symptoms. In addition these patients will be characterized for their reflux especially by pH-impedancemetry, Bilitec and oesophageal acid perfusion test. Correlations between the characteristics of the reflux and the biological results will be calculated.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Gastroesophageal Reflux

Keywords

Explore important study keywords that can help with search, categorization, and topic discovery.

GORD - Oesophageal sensitivity- Oesophageal permeability

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Observational Model Type

DEFINED_POPULATION

Study Time Perspective

PROSPECTIVE

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* Digestive symptoms suggestive of GORD (heartburn, regurgitation, epigastric pain), or dyspeptic syndrome (nausea, belch, bloating, epigastric discomfort).
* Need of upper GI endoscopy and pH monitoring.
* Normal propagation of oesophageal persitaltic waves (manometry \< 6 months).
* Age 18 -70 yrs
* Signed informed consent
* Normal coagulation

Exclusion Criteria

* Barrett's oesophagus
* Previous oesophageal bleeding
* Need of NSAID treatment.
* Previous sus mesocolic surgery
* Alcool consumption \> 40g/d, smoking \> 10 cig/j
* Pregnancy or lack of contraceptive disposal, breast feeding.
* Allergy to Xylocaïne
Minimum Eligible Age

18 Years

Maximum Eligible Age

70 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

Meet the organizations funding or collaborating on the study and learn about their roles.

Nantes University Hospital

OTHER

Sponsor Role lead

Principal Investigators

Learn about the lead researchers overseeing the trial and their institutional affiliations.

Stanislas Bruley des Varannes, Md

Role: PRINCIPAL_INVESTIGATOR

Centre Hospitalier et Universitaire de Nantes

Locations

Explore where the study is taking place and check the recruitment status at each participating site.

Nantes University Hospital

Nantes, , France

Site Status RECRUITING

Countries

Review the countries where the study has at least one active or historical site.

France

Central Contacts

Reach out to these primary contacts for questions about participation or study logistics.

Stanislas Bruley Des Varannes, MD

Role: CONTACT

Phone: (33) 240 083 306

Email: [email protected]

Facility Contacts

Find local site contact details for specific facilities participating in the trial.

Stanislas Bruley des Varannes, MD

Role: primary

Other Identifiers

Review additional registry numbers or institutional identifiers associated with this trial.

BRD 05-3-H

Identifier Type: -

Identifier Source: org_study_id