Epithelial Damage in GERD

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

34 participants

Study Classification

OBSERVATIONAL

Study Start Date

2013-04-30

Study Completion Date

2014-10-31

Brief Summary

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The purpose of this study is to characterize and compare epithelial damage in patients with erosive esophagitis and non-erosive reflux disease.

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Detailed Description

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Conditions

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Gastro-esophageal Reflux Disease

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

PROSPECTIVE

Study Groups

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Erosive Esophagitis

No interventions assigned to this group

Non-erosive Reflux Disease

No interventions assigned to this group

Heatlhy volunteers

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* Typical GERD-symptoms lasting for more than 6 months (recurrent episodes of heartburn or acid regurgitation)
* abnormal pH-parameters (pathological acid exposure and/or symptom association)

Exclusion Criteria

* Age \<18 years
* Previous esophageal or gastric surgery
* Severe esophageal motility disorder on manometry
* Histological evidence of Barrett's mucosa
* Severe co-morbidities (including cardiopulmonary disease, portal hypertension, collagen diseases, morbid obesity, coagulation disorders and co-morbidity hindering a gastroscopic procedure)
* Use of anticoagulant or immunosuppressive drugs
* Inability to stop medication that can influence the test results, like PPI, for at least 10 days before tests
* Excessive alcohol consumption (\>20 units per week)
* Patients unable to give informed consent.

Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes