Investigation of Biomarkers in Susac Syndrome

NCT ID: NCT01273792

Last Updated: 2021-07-29

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

30 participants

Study Classification

OBSERVATIONAL

Study Start Date

2010-05-31

Study Completion Date

2021-12-31

Brief Summary

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Susac Syndrome is a rare disease and the establishment of the diagnosis is often difficult. The aim of this investigation is to identify relevant biomarkers and to elucidate the pathogenesis of Susac syndrome

Detailed Description

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Susac Syndrome is a rare disease characterized by encephalopathy, branch retinal artery occlusion and sensorineural deafness. The pathogenesis is not yet clear, an autoimmune endotheliopathy is discussed. Because of the variable and often incomplete clinical presentation, the establishment of the diagnosis is often delayed or even completely missed.

The aim of this study is to identify biomarkers that facilitate the reliable and prompt establishment of the diagnosis. Patients with a definite diagnosis of Susac syndrome and healthy subjects as controls are investigated.

Furthermore, the correlation of serological markers with structural retinal and cerebral changes will contribute to clarification of the pathogenesis of Susac syndrome.

Conditions

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Susac Syndrome

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Patients with Susac syndrome

No interventions assigned to this group

Matched healthy controls

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* adult male and female patients with definite Susac syndrome or matching healthy control subjects
* ability to provide informed consent

Exclusion Criteria

* pregnancy
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Charite University, Berlin, Germany

OTHER

Sponsor Role lead

Responsible Party

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Jan-Markus Dörr

PD Dr. med.

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Jan M Dörr, MD

Role: PRINCIPAL_INVESTIGATOR

NeuroCure Clinical Research Center, Charité Universitaetsmedizin Berlin

Locations

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NeuroCure Clinical Reserach Center, Charité Universitaetsmedizin

Berlin, , Germany

Site Status RECRUITING

Countries

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Germany

Central Contacts

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Jan M Dörr, MD

Role: CONTACT

+49 30 450 ext. 660162

Facility Contacts

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Jan M Dörr, MD

Role: primary

+49 30 450 ext. 660162

References

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Dorr J, Radbruch H, Bock M, Wuerfel J, Bruggemann A, Wandinger KP, Zeise D, Pfueller CF, Zipp F, Paul F. Encephalopathy, visual disturbance and hearing loss-recognizing the symptoms of Susac syndrome. Nat Rev Neurol. 2009 Dec;5(12):683-8. doi: 10.1038/nrneurol.2009.176.

Reference Type BACKGROUND
PMID: 19953118 (View on PubMed)

Other Identifiers

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Biomarkers Susac Syndrome

Identifier Type: -

Identifier Source: org_study_id

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