Safety and Efficacy Study of the Z-Lig Medical Device Compared to Allograft

NCT ID: NCT01245400

Last Updated: 2014-03-13

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

60 participants

Study Classification

INTERVENTIONAL

Study Start Date

2010-11-30

Study Completion Date

2017-04-30

Brief Summary

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The purpose of this Trial is to demonstrate the safety and efficacy of the Investigational Device for the treatment of ruptured Anterior Cruciate Ligament (ACL) of the knee compared to Allograft.

Detailed Description

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Current techniques to reconstruct ruptured ACLs utilize either autologous tissue or allograft (cadaver) tissue. Both treatments have well-documented shortcomings (i.e., autologous tissue exposes patients to increased morbidity and allograft tissue use is limited by global availability and quality).

There are currently no effective artificial materials or xenograft tissue substitutes widely available. The purpose of this multicenter clinical trial is to evaluate the safety and efficacy of the Z-Lig in Subjects who require reconstruction of primary ruptured anterior cruciate ligaments and compare those results to allograft.

Conditions

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Ruptured Anterior Cruciate Ligaments

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

QUADRUPLE

Participants Caregivers Investigators Outcome Assessors

Study Groups

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Z-Lig

Z-Lig Anterior Cruciate Ligament Reconstruction (ACLR) graft implantation performed under anesthesia during an arthroscopic procedure.

Group Type EXPERIMENTAL

Z-Lig

Intervention Type DEVICE

ACL replacement

Allograft

Allograft bone/tendon graft implantation performed under anesthesia during an arthroscopic procedure.

Group Type ACTIVE_COMPARATOR

allograft

Intervention Type DEVICE

ACL replacement

Interventions

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Z-Lig

ACL replacement

Intervention Type DEVICE

allograft

ACL replacement

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

Contact Sponsor
Minimum Eligible Age

18 Years

Maximum Eligible Age

60 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Aperion Biologics, Inc.

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Contact Sponsor, , Belgium

Site Status

Contact Sponsor, , Denmark

Site Status

Bologna, , Italy

Site Status

Contact Sponsor, , Netherlands

Site Status

Contact Sponsor, , South Africa

Site Status

Contact Sponsor, , Spain

Site Status

Countries

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Belgium Denmark Italy Netherlands South Africa Spain

Related Links

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http://www.aperionbiologics.com/

Click here for more information about this study: Z-Lig compared to Allograft

Other Identifiers

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ABI-ZLig-01-10-01

Identifier Type: -

Identifier Source: org_study_id

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