Adaptation of Lipid and Energy Metabolism During a Lipid Overnutrition in Constitutional Thinness

NCT ID: NCT01224561

Last Updated: 2011-05-05

Basic Information

• Recruitment Status: COMPLETED
• Total Enrollment: 26 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2008-03-31
• Study Completion Date: 2011-01-31

Brief Summary

For a given food intake, fat and energy metabolism in adipose tissue and muscle adapt to nutrient intakes. This adaptation to nutrition may be impaired in susceptible individuals or in obese patients by promoting weight gain, either in constitutional thinness (MC) by blocking it. The MC is a little known entity. These patients wish to grow for her and others. Can they? We have demonstrated abnormalities of hormones regulating appetite (ghrelin, PYY, GLP1 and leptin) that may participate in thinness. Furthermore, this thinness is associated with osteoporosis in 25% of true MC who is 25 years old.

Detailed Description

This project aims to overfed MCs and follow the control parameters of energy metabolism. We will look for abnormalities in the adaptation to overnutrition in subjects with genetic background of thinness, which could explain the resistance to weight gain. The answer could possibly help to understand obesity.

Conditions

Lipid Overnutrition; Constitutional Thinness

Study Design

• Study Time Perspective: PROSPECTIVE

Study Groups

Constitutional thinness

Women with a a body mass index of less than 16.5 kg/m2

Lipid overnutrition

Intervention Type: BEHAVIORAL

During 4 months, the daily caloric intake will be increased by about 70 g fat as butter 20 grams, 100 grams of cheese (Emmental) and 40 grams of almonds. This overnutrition corresponds to an excess of 760 kcal / day or 21,280 calories for the period and then taken to a theoretical 2.4 kg of fat (1 kg fat = 9000 kcal).

Healthy Volonteer

Women with a body mass index between 20 and 25 kg/m2

Lipid overnutrition

Intervention Type: BEHAVIORAL

During 4 months, the daily caloric intake will be increased by about 70 g fat as butter 20 grams, 100 grams of cheese (Emmental) and 40 grams of almonds. This overnutrition corresponds to an excess of 760 kcal / day or 21,280 calories for the period and then taken to a theoretical 2.4 kg of fat (1 kg fat = 9000 kcal).

Interventions

Lipid overnutrition

During 4 months, the daily caloric intake will be increased by about 70 g fat as butter 20 grams, 100 grams of cheese (Emmental) and 40 grams of almonds. This overnutrition corresponds to an excess of 760 kcal / day or 21,280 calories for the period and then taken to a theoretical 2.4 kg of fat (1 kg fat = 9000 kcal).

Intervention Type: BEHAVIORAL

Eligibility Criteria

Inclusion Criteria

• consent form the study signed
• consent form for genetic study signed
• normal laboratory values for liver enzymes, glucose, lipid

Exclusion Criteria

• pregnant
• vegetarian
• heavy smoking
• heavy alcohol
• depressive
• taking hypolipidemic or antihypertensive drugs
• dyslipidemia

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 35 Years
• Eligible Sex: FEMALE
• Accepts Healthy Volunteers: Yes

Sponsors

Ministry of Health, France

OTHER_GOV

Sponsor Role: collaborator

Centre Hospitalier Universitaire de Saint Etienne

OTHER

Sponsor Role: lead

Responsible Party

Centre Hospitalier Universitaire de Saint-Etienne

Principal Investigators

Bruno ESTOUR, MD PhD

Role: PRINCIPAL_INVESTIGATOR

CHU de Saint-Etienne

Locations

CRNH Auvergne

Clermont-Ferrand, , France

CRNH Rhône-Alpes

Lyon, , France

CHU de Saint-Etienne

Saint-Etienne, , France

Countries

France

Other Identifiers

2007-A00744-49

Identifier Type: OTHER

Identifier Source: secondary_id

DGS2007-0536

Identifier Type: OTHER

Identifier Source: secondary_id

0701047

Identifier Type: -

Identifier Source: org_study_id