Impaired Regulation of Energy Balance in Elderly People (Balance Study)
NCT ID: NCT00561145
Last Updated: 2016-03-11
Study Results
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View full resultsBasic Information
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COMPLETED
NA
32 participants
INTERVENTIONAL
2007-10-31
2012-03-31
Brief Summary
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The first objective of this study is to provide further evidence for an age-related failure to regulate energy balance in elderly. If the hypothesis of impaired regulation of energy balance in elderly is confirmed then the second objective becomes to elucidate the underlying physiological mechanisms of the age-related failure to regulate energy intake in elderly.
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Detailed Description
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Conditions
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Study Design
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NON_RANDOMIZED
PARALLEL
BASIC_SCIENCE
NONE
Study Groups
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Young men
Energy restriction period
Energy restriction period
The experiment can be divided in 3 phases, namely (1) run-in phase, (2) energy restriction phase and (3) ad libitum food intake phase. Thus, for all participants the experiment consists of three subsequent phases.
Elderly men
Energy restriction period
Energy restriction period
The experiment can be divided in 3 phases, namely (1) run-in phase, (2) energy restriction phase and (3) ad libitum food intake phase. Thus, for all participants the experiment consists of three subsequent phases.
Interventions
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Energy restriction period
The experiment can be divided in 3 phases, namely (1) run-in phase, (2) energy restriction phase and (3) ad libitum food intake phase. Thus, for all participants the experiment consists of three subsequent phases.
Eligibility Criteria
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Inclusion Criteria
* healthy
* 20-40 and 65-85 years of age
* normal weight
* free-living in Wageningen and surrounding
Exclusion Criteria
* diabetes
* restrained eating
* dementia
* weight changes of \> 2 kg during the last 2 months
20 Years
85 Years
MALE
Yes
Sponsors
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Dutch Dairy Organization (NZO)
OTHER
Wageningen University
OTHER
Responsible Party
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Lisette de Groot
Professor
Principal Investigators
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Lisette de Groot, Prof, PhD
Role: PRINCIPAL_INVESTIGATOR
Wageningen University
Locations
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Wageningen University, Division of Human Nutrition
Wageningen, Gelderland, Netherlands
Countries
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References
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Winkels RM, Jolink-Stoppelenburg A, de Graaf K, Siebelink E, Mars M, de Groot L. Energy intake compensation after 3 weeks of restricted energy intake in young and elderly men. J Am Med Dir Assoc. 2011 May;12(4):277-86. doi: 10.1016/j.jamda.2010.08.011. Epub 2010 Oct 20.
Van Bussel IP, Jolink-Stoppelenburg A, De Groot CP, Muller MR, Afman LA. Differences in genome-wide gene expression response in peripheral blood mononuclear cells between young and old men upon caloric restriction. Genes Nutr. 2016 May 6;11:13. doi: 10.1186/s12263-016-0528-0. eCollection 2016.
Other Identifiers
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NL 17278.081.07
Identifier Type: -
Identifier Source: org_study_id
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