The Effects of Overfeeding on Obesity-Prone (OP) and Obesity-Resistant (OR) Women

NCT ID: NCT00072917

Last Updated: 2010-01-18

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

100 participants

Study Classification

OBSERVATIONAL

Study Start Date

2003-10-31

Study Completion Date

2008-06-30

Brief Summary

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This is a longitudinal cohort study of how the responses to a 3 day period of controlled overfeeding relate to subsequent weight gain. We hypothesize that thin individuals are resistant to weight gain because they respond to periods of overfeeding by increasing fat oxidation, reducing food intake, and increasing physical activity relative to those who gain weight over time.

Detailed Description

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Conditions

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Obesity Thinness Weight Gain

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Eligibility Criteria

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Inclusion Criteria

* Half of the subjects will be women, half will be men,
* age 25-35,
* a range of BMI's from 19-27, for the 'thin subjects' there should be no 1st degree relatives with a BMI\>30.
* Subjects should not engage in planned physical activity more than 3 hrs per week.
* For the obesity prone group there should be at least 1 1st degree relative with a BMI\>30.
Minimum Eligible Age

25 Years

Maximum Eligible Age

35 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

NIH

Sponsor Role lead

Responsible Party

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University of Colorado School of Medicine

Locations

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University of Colorado Health Sciences Center

Denver, Colorado, United States

Site Status

Countries

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United States

References

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Rynders CA, Pereira RI, Bergouignan A, Kealey EH, Bessesen DH. Associations Among Dietary Fat Oxidation Responses to Overfeeding and Weight Gain in Obesity-Prone and Resistant Adults. Obesity (Silver Spring). 2018 Nov;26(11):1758-1766. doi: 10.1002/oby.22321.

Reference Type DERIVED
PMID: 30358145 (View on PubMed)

Creasy SA, Rynders CA, Bergouignan A, Kealey EH, Bessesen DH. Free-Living Responses in Energy Balance to Short-Term Overfeeding in Adults Differing in Propensity for Obesity. Obesity (Silver Spring). 2018 Apr;26(4):696-702. doi: 10.1002/oby.22121.

Reference Type DERIVED
PMID: 29570248 (View on PubMed)

Other Identifiers

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DK62874

Identifier Type: -

Identifier Source: secondary_id

OVOPOB DK62874 (complted)

Identifier Type: -

Identifier Source: org_study_id

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