Effects of Physical Activity on the Brain in Impaired Glucose Tolerance (IGT)

NCT ID: NCT01219231

Last Updated: 2016-03-16

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE4

Total Enrollment

46 participants

Study Classification

INTERVENTIONAL

Study Start Date

2010-08-31

Study Completion Date

2015-01-31

Brief Summary

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The researchers will investigate whether exercise could provide positive effects on general brain functions in elderly people with impaired glucose tolerance.

Detailed Description

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The age-related degradation of cognitive functions even to the point of neurodegenerative disorders such as Alzheimer's disease are a growing public-health concern with devastating effects.

Referring to animal data, empirical studies, and pilot human trials, exercise should improve cognitive functions such as learning and memory. To test this hypothesis, the researchers study general brain functions in elderly subjects (50-80 years old) with impaired glucose tolerance during a short term exercise program.

Conditions

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Impaired Glucose Tolerance

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

PREVENTION

Blinding Strategy

QUADRUPLE

Participants Caregivers Investigators Outcome Assessors

Study Groups

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Exercise

Group Type EXPERIMENTAL

Exercise

Intervention Type BEHAVIORAL

6 months of aerobic exercise

Placebo

Group Type PLACEBO_COMPARATOR

Exercise

Intervention Type BEHAVIORAL

6 months of aerobic exercise

Interventions

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Exercise

6 months of aerobic exercise

Intervention Type BEHAVIORAL

Eligibility Criteria

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Inclusion Criteria

* subjects with impaired glucose tolerance
* 50-65 years old
* moderate to heavy weight (BMI 25-35)
* must be able to do exercise intervention

Exclusion Criteria

* diabetes
* younger than 50 years
* BMI \< 25
* psychiatric medication
* severe disease
* MMSE \< 26
* severe cardiovascular disorders
Minimum Eligible Age

50 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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German Federal Ministry of Education and Research

OTHER_GOV

Sponsor Role collaborator

Charite University, Berlin, Germany

OTHER

Sponsor Role lead

Responsible Party

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Agnes Flöel

Prof

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Agnes Flöel, MD, Prof.

Role: PRINCIPAL_INVESTIGATOR

Charité University Berlin

Locations

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Department of Neurology, Charité Universitätsmedizin

Berlin, State of Berlin, Germany

Site Status

Countries

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Germany

Other Identifiers

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exercise_neuromod

Identifier Type: -

Identifier Source: org_study_id

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